000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20220125142842.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
220125b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
10280 |
Author |
Banerjee, Kaushik |
245 ## - TITLE STATEMENT |
Title |
Modulation of morphology and efficacy of new CB1 receptor antagonist using simple and benign polymeric additives |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol.60(B), July |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
New Delhi |
Name of publisher, distributor, etc. |
CSIR |
Year |
2021 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
1014-1021p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
The compound 1, [(1H-[1]benzoxepino[5,4-c]pyrazole-3-carboxamide, 8-chloro-1-(2,4-dichlorophenyl)-4,5-dihydro-N- 1-piperidinyl], a known CB1 modulator has been synthesized and characterized by IR, NMR and single Crystal X-ray study. The single crystal study of 1 displays a number of halogen bonds leading to 1-D network along with other weak noncovalent interactions. The CB1 modulator 1 inherently possesses extremely low solubility in water, which makes its application as drug difficult, and this may be attributed to multiple halogen bonds present in the crystal structure. A series of polymer additives, which are Generally Regarded As Safe (GRAS), have been explored to investigate whether they can modulate the halogen bond present in 1 through formation of various non-bonded interactions. Surprisingly, these polymers are found to change crystal morphology, crystal packing while retaining efficacy and bioavailability. The polymer molecular weight is found to play a significant role in crystal morphology modification especially in case of polyethylene glycol (PEG). The formation of new polymorphic forms of 1 and modification of halogen bond has been established using powder X-ray diffraction and IR study, respectively, in case of PEG 4000, PVPK-30, PVA polymers and compound 1 adducts. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
5009 |
Topical term or geographic name entry element |
GENERAL CHEMISTRY |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
15601 |
Co-Author |
Patel, Darshit R. |
773 0# - HOST ITEM ENTRY |
Title |
Indian journal of chemistry (Section B) |
Place, publisher, and date of publication |
New Delhi NISCAIR-CSIR 2005 |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
http://nopr.niscair.res.in/bitstream/123456789/58176/1/IJC%20%28Section%20B%29%2c%2060B%2c%201014-1021%20%28Jul%2c2021%29.pdf |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |