| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220204103245.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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220204b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15841 |
| Author |
Desai, Juhi |
| 245 ## - TITLE STATEMENT |
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| Title |
Development of green coffee beans extract loaded anti-aging liposomal gel |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.55(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Karnataka |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
978-988p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background: Green beans of Coffee arabica L. Family: Rubiacea are rich source of polyphenols that prevents the oxidative damage to the skin. In this study, Liposomes were formulated as drug carrier to enhance the skin permeability of polyphenols for topical administration. Materials and Methods: Extracts of green coffee beans were prepared by varying the ratios of methanol and water. Phytochemical analysis and in vitro antioxidant evaluation was conducted on all the extracts to choose the best extract for further studies. The cytotoxicity potential (MTT assay) and anti-elastase activity of chosen extract was evaluated on L929 cell lines using flow cytometer. The liposomes of the extract was prepared by thin film hydration method and optimized by varying the phosphatidylcholine to cholesterol ratio and gradually increasing the amount of extract. Liposomal formulation was converted into gel using carbopol ® 974P as gelling agent. The prepared liposomal suspension and liposomal gel was evaluated for various formulation parameters. Results: The results of phytochemical analysis, in vitro antioxidant assays and in vitro evaluation on L929 cell lines concluded that 25% methanolic extract was nontoxic with highest phenolic content and exhibited good antielastase activity. The encapsulation efficiency of chlorogenic acid in the optimized liposomal formulation was 75%. The liposomal gel showed sustained release of the drug upto 12 hr compared to 6-7 hr of conventional formulation. Conclusion: The formulated green coffee bean extract loaded liposomal based gel may serve as potential carrier for antiaging effects. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15842 |
| Co-Author |
Mallya, Rashmi |
| 773 0# - HOST ITEM ENTRY |
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| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title |
Indian journal of pharmaceutical education and research |
| International Standard Serial Number |
0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-4-979.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
