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OSt |
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20220209133508.0 |
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220209b xxu||||| |||| 00| 0 eng d |
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AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15988 |
| Author |
Shougrakpam, Priyadarshini |
| 245 ## - TITLE STATEMENT |
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| Title |
Comparative study of anticonvulsant effect of the leaves of sapindus emarginatus and acorus calamus in experimentally induced animal models of epilepsy |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.13(1) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
M P |
| Name of publisher, distributor, etc. |
Innovare Academic Sciences Pvt Ltd |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
36-39p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Objective:To compare anticonvulsant activity of methanol extracts of Sapindus emarginatus (MESE) and Acorus calamus (MEAC) in experimental seizure models in mice. Methods:Hind limb tonic extension (HLTE) in Maximal electroshock (MES)seizureand clonic seizure in Pentylenetetrazol (PTZ) seizure models were assessed. Group I (control) mice received 1% gum acacia in distilled water (1 ml/100 g). Topiramate (50 mg/kg) was administered in group II (standard) animals. Group III and IV mice were treated with 200 and 400 mg/kg of MESE, respectively. Mice in group V and VI were given MEAC at the dose of 200 and 400 mg/kg, respectively. Drugs were given orally suspended in 1% gum acacia suspension (1 ml/100 g) for 7 d. Next day after 1 h of drug administration, the seizure was induced for evaluation.Results: Anticonvulsant property of both extracts was confirmed by reduction (p<0.001) in HLTE phase in MES model; delayed onset of the clonic seizure (p<0.001) and its shortened phase (p<0.001) in PTZ model when compared with the control. MESE-200 mg/kg produced significantlylonger (p<0.001) HLTE phase with lower protection (40.34%) among the different doses of the extracts. Clonic seizure onsets and durations in PTZmodel were comparable among the different extract-treated groups; however, mortality was higher (66.6%) with MESE-200 mg/kg.Conclusion: Anticonvulsant activity of MESE and MEAC was evident; however, MESE at the dose of 200 mg/kg was less effective. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15989 |
| Co-Author |
Bhattacharjee, Abhishek |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
2656-0097 |
| Place, publisher, and date of publication |
Bhopal Innovare Academic Sciences Pvt Ltd |
| Title |
International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://innovareacademics.in/journals/index.php/ijpps/article/view/39872/24085 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
