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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20220210110706.0 |
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220210b xxu||||| |||| 00| 0 eng d |
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AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
16021 |
| Author |
Ghani, Eman M. Abdel |
| 245 ## - TITLE STATEMENT |
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| Title |
Chemical and biological analysis of the bioctive fractions of the leaves of scaevola taccada (GAERTN.) roxb |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.13(3) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
M P |
| Name of publisher, distributor, etc. |
Innovare Academic Sciences Pvt Ltd |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
35-41p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Objective: Scaevola taccada. (Gaertn.) Roxb. is widely dispersed all along the coasts of Africa. It is used in folk medicine for diversity of ailments. This study aims to investigate the major phytoconstituents and biological activities of the leaves of S. taccada(Gaertn.) Roxb.Methods: In vitrobiological examination viz. antimicrobial, cytotoxic and antioxidant activities of the ethanol extract of the leaves (EE) and its fractions; (petroleum ether (PE), methylene chloride (MC), ethyl acetate (EA) and n-butanol(BuOH)) were carried out. Estimation of the phytochemicals of biologically active fractions was done. Results: n-butanol fraction displayed remarkable antimycobacterium activity. Petroleum ether as well as n-butanol fractions evidenced a cytotoxic effect on breast carcinoma cell line (MCF7) and colon carcinoma cell line (HCT) with IC50 11.7 and 15.04 μg/ml respectively. Moreover, ethyl acetate fraction exhibits an antioxidant effect with EC50 476.7±0.57 μg/ml. n-tetradecane1, α-amyrin palmitate 2, α-amyrin acetate 3, α-amyrin 4, stigmasterol 5, luteolin-7-O-β-glucoside 6, rutin 7 and alidyjosioside 8 were identified in S. taccada(Gaertn.) Roxb. leaves.Conclusion: Petroleum ether fraction is a cytotoxic candidate, especially against (MCF-7). It exhibited a moderate antifungal and antibacterial againstcertain Gram-positive bacteria. Ethyl acetate showed an antioxidant effect along with moderate antifungal activity. n-butanol fraction exerted potential antimycobacterial, significant cytotoxic activity against (HCT), good antifungal and antibacterial against Gram-positive and Gram-negative bacteria. Stigmasterol,luteolin-7-O-β-glucoside, rutin and alidyjosioside were isolated for the first time from S. taccada(Gaertn.) Roxb. Leaves. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
16022 |
| Co-Author |
Sayed, Abeer M. EL |
| 773 0# - HOST ITEM ENTRY |
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| Title |
International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number |
2656-0097 |
| Place, publisher, and date of publication |
Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.innovareacademics.in/journals/index.php/ijpps/article/view/40257/24435 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
