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| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20220210141144.0 |
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220210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
16037 |
| Author |
Karki, Yashoda |
| 245 ## - TITLE STATEMENT |
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| Title |
Antioxidant, PTP 1B inhibition and α-amylase inhibition property and gc-ms analysis of methanolic leaves extract of achyranthes aspera and catharanthus roseus of Nepal |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.13(4) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
M P |
| Name of publisher, distributor, etc. |
Innovare Academic Sciences Pvt Ltd |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
49-55p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Objective:The present study was designed to study phytochemicals and biological activities of the methanolic extracts of two traditional medicine plants Achyranthes aspera and Catharanthus roseus of Nepalese origin.Methods:Plant extracts were prepared by cold percolation method. Antioxidant activity, brine shrimp lethality assay, and analysis of phytochemical constituents were carried out using standard methods. The dinitro salicylic acid (DNS) method was used to study the inhibition effect of extracts on α-amylase enzyme. Furthermore, PTP 1B inhibitory activity was evaluated usingp-nitrophenyl phosphate (p-NPP) as substrate.Results:Phytochemical analysis showed the presence of phytochemicals like alkaloids, flavonoids, glycosides, reducing sugars, etc. in both plants. Brine shrimp lethality assay suggested the presence of pharmacologically active compounds. Total phenolic content and total flavonoid content of C. roseus were found to be higher with 73.21 mg GAE/g and 33.15 mg Q/g respectively than that of A. aspera, which was found to be 57.09 mg GAE/g and 28.96 mg Q/g respectively. Similarly, the α-amylase inhibition of A. asperaand C. roseus was found to be 97.60±1.11 μg/ml and 94.05±1.18 μg/ml comparative with IC50 68.13±0.46 μg/ml of standard acarbose. Protein tyrosine phosphatase 1B (PTP1B) inhibition showed IC50 for A. asperaand C. roseus to be 48.72±0.46 and 50.21±1.03 μg/ml, respectively. Qualitative GC-MS analysis of both plant hexane fractions showed acid and ester type of phytoconstituents.Conclusion:These results suggested that both plants i. e A. asperaand C. roseus, Nepal origin showed biological activity by targeting multiple drug targets which justifies their traditional uses. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
16038 |
| Co-Author |
Deegendra, Khadka |
| 773 0# - HOST ITEM ENTRY |
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| Title |
International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number |
2656-0097 |
| Place, publisher, and date of publication |
Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://innovareacademics.in/journals/index.php/ijpps/article/view/40490/24650 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Articles Abstract Database |
