000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20220211101809.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
220211b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
16061 |
Author |
Shah, Virag A. |
245 ## - TITLE STATEMENT |
Title |
Optimization and characterization of doxorubicin loaded solid lipid nanosuspension for nose to brain delivery using design expert software |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol.13(5) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
M P |
Name of publisher, distributor, etc. |
Innovare Academic Sciences Pvt Ltd |
Year |
2021 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
45-57p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Objective: The goal of the current study was to investigate the possible use of solid lipid nanosuspension (SLNs) as a drug delivery method to boost doxorubicin (DOX) brain-targeting performance after intranasal (i. n.) administration.Methods: 33 factorial design was applied for optimization by using lipid concentration, surfactant concentration, and High-speed homogenizer (HSH) stirring time as dependent variables, and their effect was observed on particles size, Polydispersity index (PDI), and entrapment efficiency.Results: With the composition of Compritol® 888 ATO (4.6 % w/v), tween 80 (1.9 % w/v), and HSH stirring time, the optimized formula DOX-SLNs prepared (10 min). Particle size, PDI, zeta potential, entrapment efficiency, percent in vitro release were found to be 167.47±6.09 nm, 0.23±0.02, 24.1 mV, 75.3±2.79, and 89.35±3.27 percent in 24 h, respectively, for optimized formulation (V-O). No major changes in particle size, zeta potential, and entrapping efficiency were found in the stability studies at 4±2 °C (refrigerator) and 25±2 °C/60±5% RH up to 3 mo.Conclusion: Keywords: Solid lipid Nanosuspension, Homogenization and Ultrasonication, Characterization, Factorial design, Nose to brain deliveryFollowing the non-invasive nose-to-brain drug delivery, which is a promising therapeutic strategy, the positive findings confirmed the current optimized DOX-loaded SLNs formulation. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
16062 |
Co-Author |
Jayvadan K. Patel |
773 0# - HOST ITEM ENTRY |
Place, publisher, and date of publication |
Bhopal Innovare Academic Sciences Pvt Ltd |
International Standard Serial Number |
2656-0097 |
Title |
International journal of pharmacy and pharmaceutical science |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
https://innovareacademics.in/journals/index.php/ijpps/article/view/41137/24726 |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |