CODESTM drug delivery: design and evaluation of metronidazole tablets (Record no. 16971)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220629155136.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220629b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16911 |
| Author | Derfla, A. P. |
| 245 ## - TITLE STATEMENT | |
| Title | CODESTM drug delivery: design and evaluation of metronidazole tablets |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | BRNSS Publication Hub. |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 400-405p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: The present study aimed to develop and demonstrate the study of combined effects of biodegradable polymer coated with different pH-sensitive polymers in the formulation of Metronidazole tablets for colon targeted drug delivery. Materials and Methods: Metronidazole Hydrochloride is cored with various proportions of biodegradable polymers such as xanthan gum and chitosan. Then, the double-layered system was designed based on pH-sensitive eudragit S100 and eudragit L100 as an inner layer and outer layer, respectively. To evaluate the in-vitro dissolution profile of CODESTM tablets in gastrointestinal fluids, the test was performed using three consecutive media and drug release kinetics are performed. The drug excipient interaction of CODESTM formulation was characterized by Fourier transform infrared (FT-IR). Results and Discussion: From the in-vitro drug release studies, F6 tablets were considered as the optimized formulation, which retard the drug release in the stomach (pH 1.2) and small intestine (pH 7.4) and progressively increase the release of 75.75% in the colon (pH 6.8) due to mucoadhesive properties of chitosan. The FT-IR analysis shows that there is no interaction between drug and excipient. The drug release kinetics followed supercase – II transport with erosion mechanism. Conclusion: Briefly to conclude that CODESTM technology is a promising method for approach to deliver drug to colon due to the controlled release of biodegradable polysaccharides and gastric resistance polymer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16904 |
| Co-Author | Subramanian, S. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of green pharmacy |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.greenpharmacy.info/index.php/ijgp/article/view/3187 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-06-29 | 2022-0968 | 2022-06-29 | 2022-06-29 | Articles Abstract Database |