Assessment of polymeric nanoparticles to enhance oral bioavailability and antioxidant activity of resveratrol (Record no. 17223)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220729103719.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220729b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17388 |
| Author | Hasija, R. |
| 245 ## - TITLE STATEMENT | |
| Title | Assessment of polymeric nanoparticles to enhance oral bioavailability and antioxidant activity of resveratrol |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1114-1128p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Resveratrol has proven as potential natural antioxidant, non-flavonoid polyphenolic compound, but it has limitations such as low water solubility, which substantially restricts oral bioavailability. To enhance oral bioavailability and antioxidant potential of resveratrol by fabricating the resveratrol encapsulated oral eudragit® E100 based polymeric nano-delivery system. Resveratrol-encapsulated polymeric nanoparticles were developed by solvent extraction and diffusion method. Copolymer, eudragit® E100 polymeric matrices were used to prepared polymeric nanoparticles and in vitro physicochemically characterized. Furthermore, in vivo pharmacokinetic and antioxidant potential of optimized resveratrol-encapsulated polymeric nanoparticles was evaluated. The resveratrol-encapsulated polymeric nanoparticles exhibited optimum mean particle size (410±9.78 nm), polydispersity index (0.203±0.079) and encapsulation efficiency (66.88±5.45 %), respectively. In vitro release profile of resveratrol showed >25 % release in first 2 h in phosphate-buffered saline pH 7.4 followed by >75 % at the end of 48 h. The optimized resveratrol- encapsulated polymeric nanoparticles were stable at the accelerated condition and room temperature, respectively. The optimized resveratrol-encapsulated polymeric nanoparticles demonstrated significantly higher oral bioavailability (~4.07-fold; p<0.05) as compared to pure resveratrol. Furthermore, the optimized resveratrol-encapsulated polymeric nanoparticles were evaluated for free radical scavenging activity and showed to increase the activity with time i.e. after 72 h, it was the same as pure resveratrol but at 24 h no increase in antioxidant activity was observed with optimized resveratrol-encapsulated polymeric nanoparticles. Furthermore, half-maximal inhibitory concentration of the optimized resveratrol- encapsulated polymeric nanoparticles was decreased with time. Results are suggesting that resveratrol- encapsulated polymeric nanoparticles are the promising approach using eudragit® E100 as a polymeric material to enhance oral bioavailability and antioxidant potential of insoluble resveratrol. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17389 |
| Co-Author | Chaurasia, S. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/assessment-of-polymeric-nanoparticles-to-enhance-oral-bioavailability-and-antioxidant-activity-of-resveratrol.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-07-29 | 2022-1220 | 2022-07-29 | 2022-07-29 | Articles Abstract Database |