Toxicity effects of oral administration of clinacanthus nutans ethanolic leaf extract on blood, liver and kidneys of mice (Record no. 17231)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220730101552.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220730b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17402 |
| Author | Aliyu, A. |
| 245 ## - TITLE STATEMENT | |
| Title | Toxicity effects of oral administration of clinacanthus nutans ethanolic leaf extract on blood, liver and kidneys of mice |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1181-1195p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Clinacanthus nutans has been used traditionally in the treatment of herpes simplex viral infection. This research evaluated the toxicity effects of sub-chronic oral administration of Clinacanthus nutans ethanolic leaf extract in Institute of Cancer Research mice. A total 50, 8 w old female mice were divided into five groups of 10 mice each; Group A (control), Group B (125 mg/kg), Group C (250 mg/kg), Group D (500 mg/kg) and Group E (1000 mg/kg). The extract was administered orally for 90 d. The mice were monitored and sacrificed on d 91. Blood, liver and kidney samples were collected for analyses. There was significant (p<0.05) alterations in the haematological parameters of the mice in Group E and a significant increase in creatinine levels in groups B, C, D and E compared to A. The plasma level of alanine aminotransferase was significantly (p<0.05) higher in Groups D and E, compared to A. Histopathological evaluation of liver and kidneys revealed a moderate cytoplasmic vacuolation, eosinophilic cytoplasm and pyknosis of hepatocytes, as well as mild to moderate activated Kupffer cells in Group E. Similarly, the renal tubular cells showed mild to moderate renal cytoplasmic vacuolation, eosinophilic cytoplasm, pyknotic and karyolytic cells in Group E. It is concluded that repeated oral doses of Clinacanthus nutans ethanolic leaf extract for 90 d induced hepato-renal toxicities in female Institute of Cancer Research mice. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17405 |
| Co-Author | Shaari, M. R. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/toxicity-effects-of-oral-administration-of-emclinacanthus-nutansem-ethanolic-leaf-extract-on-blood-liver-and-kidneys-of-.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-07-30 | 2022-1233 | 2022-07-30 | 2022-07-30 | Articles Abstract Database |