Development and characterization of oral fast-dissolving strip incorporated with olmesartan medoxomil nanocrystals for solubility enhancement (Record no. 17236)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220730143935.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220730b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17412 |
| Author | Rajakumari, V. |
| 245 ## - TITLE STATEMENT | |
| Title | Development and characterization of oral fast-dissolving strip incorporated with olmesartan medoxomil nanocrystals for solubility enhancement |
| Remainder of title | : Multilevel categoric optimization using DOE |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.16(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | BRNSS Publication Hub. |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 172-182p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: Olmesartan medoxomil (OLM) is an antihypertensive drug available as an oral solid dosage form (tablet) with a restricted bioavailability of 28.6%. This might be attributed due to the low solubility and low permeability of the drug. The primary goal of this study was to enhance the solubility of OLM by formulating OLM nanocrystals (NC) and incorporating them into Oral Fast-Dissolving Strips (OFDSs) that will be made available for geriatric patients. Materials and Methods: Initially, nanosuspension (solvent-anti-solvent addition) was prepared using different concentrations of stabilizers and characterized for particle size (PS), polydispersity index (PDI), and zeta potential. Further, the nanosuspension was freeze-dried to obtain NC and it was characterized for crystallinity and surface morphology. In addition, the OLM NCs were incorporated into OFDS (solvent evaporation technique) and optimized by Multilevel Categoric design (24 × 2 2) using Design Expert® software. The OFDS was evaluated for weight variation, thickness, tensile strength, drug content, disintegration time, and dissolution. Results and Discussion: F30 shows PS, PDI, and zeta potential of 764.6 nm, 0.310, and −28.7 mV, respectively. The DSC thermograms showed that the reduction in crystallinity of OLM NC compared to pure OLM and the SEM images reveal rod-shaped crystals. The weight variation, thickness, surface pH, and drug content of OLM loaded OFDS obtained satisfactory results. The disintegration time, folding endurance, and tensile strength of the optimized formulation were found to be 20 ± 0.41 s, 125 ± 0.47 times, and 1328.8 ± 0.82 N/m, respectively. The drug release from the formulation was found to be 85.28% at the end of 5 min; the drug release kinetics indicated that it follows non-fickian diffusion and stability studies (25°C/60% RH) reveal that the formulation was stable. Conclusion: The results conclude that NCs approach is a promising techniques to improve solubility of poorly soluble drug. Key words: Design of experiment, nanocrystals, olmesartan medoxomil, oral fast-dissolving strip, solvent evaporation, solvent-antisolvent addition |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17400 |
| Co-Author | Nithya, R. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of green pharmacy |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| International Standard Serial Number | 0973-8258 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.greenpharmacy.info/index.php/ijgp/article/view/3251 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| Not For Loan | Reference | School of Pharmacy | School of Pharmacy | Archieval Section | 2022-07-30 | 2022-1238 | 2022-07-30 | 2022-07-30 | Articles Abstract Database |