Astragalus polysaccharide regulates proliferation, migration and invasion of lung cancer cells via janus kinase/signal transducer and activator of transcription signaling pathway (Record no. 17238)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220730145257.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220730b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17413 |
| Author | Cai, H. |
| 245 ## - TITLE STATEMENT | |
| Title | Astragalus polysaccharide regulates proliferation, migration and invasion of lung cancer cells via janus kinase/signal transducer and activator of transcription signaling pathway |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1215-1220p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To evaluate the regulatory effects of Astragalus polysaccharide on the proliferation, migration and invasion of lung cancer cells via the Janus kinase/signal transducer and activator of transcription signaling pathway. The inhibitory effects of treatment with Astragalus polysaccharide at different concentrations (0, 0.5, 1.0, 2.0, 4.0, 8.0 and 16.0 mg/ml) for different time (24, 48 and 72 h) on the proliferation of adenocarcinomic human alveolar basal epithelial cells in the logarithmic growth phase were detected by methyl thiazolyl tetrazolium assay and its inhibitory effects on the migration and invasion of adenocarcinomic human alveolar basal epithelial cells were determined by wound healing assay and Transwell migration and invasion assays respectively. In contrast with control group, the proliferation of adenocarcinomic human alveolar basal epithelial cells treated with different concentrations of Astragalus polysaccharide for 24, 48 and 72 h was remarkably inhibited in a dose and time dependent manner under the same drug concentration, longer the action time, higher the proliferation inhibition rate of adenocarcinomic human alveolar basal epithelial cells; under the same action time, higher the drug concentration, higher the proliferation inhibition rate of adenocarcinomic human alveolar basal epithelial cells. The number of migrating cells dropped significantly in Astragalus polysaccharide groups (p<0.05), which was more obvious with the increase of Astragalus polysaccharide concentration (p<0.05). Astragalus polysaccharide can dramatically inhibit the proliferation of lung cancer adenocarcinomic human alveolar basal epithelial cells in a concentration and time-dependent manner and also effectively suppress their migration and invasion. The mechanism may be related to its ability to up-regulate the protein expressions of Src homology region 2 containing protein tyrosine phosphatase 2 and suppressor of cytokine signaling 3 and inhibit the over-activation of the Janus kinase/signal transducer and activator of transcription signaling pathway in lung cancer adenocarcinomic human alveolar basal epithelial cells. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17424 |
| Co-Author | Cao, J. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/emastragalusem-polysaccharide-regulates-proliferation-migration-and-invasion-of-lung-cancer-cells-via-janus-kinasesignal.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-07-30 | 2022-1240 | 2022-07-30 | 2022-07-30 | Articles Abstract Database |