Novel glibenclamide–phospholipid complex for diabetic treatment: formulation, physicochemical characterization, and in-vivo evaluation (Record no. 17325)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220825143306.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220825b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17593 |
| Author | Rathor, Sandeep |
| 245 ## - TITLE STATEMENT | |
| Title | Novel glibenclamide–phospholipid complex for diabetic treatment: formulation, physicochemical characterization, and in-vivo evaluation |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 697-705p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Formulation of phospholipid complex is an ideal approach to improve the solubility of poorly soluble drugs. Objectives: This study has been aimed to prepare a novel glibenclamide-phospholipid complex by using the solvent evaporation technique. Materials and Methods: Because glibenclamide is a weakly soluble medication, complexing it with phospholipids is an excellent way to enhance its solubility. The phospholipid complex of Glibenclamide was produced using the solvent-evaporation technique to enhance its oral efficacy. The formulation was characterized and evaluated by various parameters including FTIR, DSC, PXRD, SEM, TEM, in vitro drug release, and in vivo pharmacokinetic studies in Wistar rats plasma. According to studies, the Glibenclamide phosphates combination is significantly more water-soluble than the physical combination and pure Glibenclamide. The oral bioavailability of the glibenclamide-phospholipids complex was measured by using HPLC in Wistar rats’ plasma. Results: There was no substantial interaction between the medication and the phospholipid in the formulation, according to the FTIR and PXRD findings. The morphology of the formulation was verified by SEM and TEM investigations, indicating that the crystalline form had been converted to an amorphous form. The glibenclamide-phospholipids complex had a greater peak plasma concentration (5.1 vs. 3.8 g/mL), its AUC was higher (14.65 vs. 11.81 μgh/L), and its T1/2 was longer (2.4 vs. 3.1 hr), showing that it enhanced drug dissolution rate. Conclusion: The findings showed that increasing the oral bioavailability of water- insoluble medicines by phospholipid-complexation is a potential approach. The results showed that phospholipid-complexation may be used to enhance the oral bioavailability of water-insoluble drugs. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17594 |
| Co-Author | Bhatt, D.C. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-697_0.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-25 | 2022-1375 | 2022-08-25 | 2022-08-25 | Articles Abstract Database |