Solubility enhancement of lawsone by complexation with beta cyclodextrin (Record no. 17327)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220825150639.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220825b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17596 |
| Author | Francis, Shincy Mariya |
| 245 ## - TITLE STATEMENT | |
| Title | Solubility enhancement of lawsone by complexation with beta cyclodextrin |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 706-715p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Lawsone is a phyto-constituent obtained from the leaves of the Lawsonia inermis. It has antibacterial, antifungal, antiviral, wound healing, antiparasitic, tuberculostatic, anti-fertility, analgesic, anti-inflammatory, enzyme inhibitory, nematicidal, anticoagulant, and protein glycation inhibitory activities. It has poor water solubility (hydrophobic), poor bioavailability, and poor dissolution characteristics. Aim: The purpose of this research is to improve the aqueous solubility of Lawsone by preparing the inclusion complexes of Lawsone with beta-cyclodextrin. Materials and Methods: Inclusion complexes of Lawsone were prepared by different methods such as physical mixture, kneading method and co-precipitation method. Characterization of the complexes were done by Fourier Transform Infrared (FTIR) spectroscopy and in vitro dissolution study. Differential scanning calorimetry (DSC), Nuclear Magnetic Resonance spectroscopy (NMR), and Powder X-Ray Diffraction (PXRD). were used to evaluate the co-precipitation technique inclusion complexes. Antimicrobial studies of complexes against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) , Bacillus subtilis (B. subtilis), and Pseudomonas aeruginosa (P. aeruginosa ) were done by colony counting method. Results: Phase solubility study revealed the molar ratio of Lawsone to beta- cyclodextrin in the complex is 1:1. At the third hour, the drug release was 64%, 78%, 93%, and 97% for pure drug, physical mixture, inclusion complexes formed by kneading technique and co-precipitation technique respectively. DSC, NMR, and PXRD confirmed the formation of complexes of Lawsone. The order of antibacterial activity of inclusion complexes was E. coli > B. subtilis > P. aeruginosa > S. aureus. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17597 |
| Co-Author | Xavier, Elizabeth N. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-706.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-25 | 2022-1377 | 2022-08-25 | 2022-08-25 | Articles Abstract Database |