Hydroalcoholic carthamus tinctorius l. Extract attenuates tnbs-induced ulcerative colitis in mice via downregulation of inflammation and oxidative stress (Record no. 17337)
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| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220826111337.0 |
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| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17615 |
| Author | Li, Zhang |
| 245 ## - TITLE STATEMENT | |
| Title | Hydroalcoholic carthamus tinctorius l. Extract attenuates tnbs-induced ulcerative colitis in mice via downregulation of inflammation and oxidative stress |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 780-788p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Ulcerative colitis (UC) is distinct by severe inflammation of intestinal epithelial tissue and more than 2 million people worldwide are affected with ulcerative colitis. This disease is primarily driven by oxidative stress and inflammation. Objectives: To identify a safer remedy with less/no adverse effect, we investigated the beneficial ability of Carthamus tinctorius L. extracts to alleviate multi-factorial conditions like oxidative stress, lipid peroxidation, and inflammation in Trinitro benzenesulfonic acid induced experimental ulcerative colitis in mice. Materials and Methods: Ulcerative colitis in Balb/c mice were induced by intrarectal administration of TNBS. Hydroalcoholic Carthamus tinctorius L. extracts were supplemented orally and all mice were observed and scored for clinical manifestations. After sacrificing mice, inflammatory markers, colonic oxidative stress levels, and antioxidant enzymes were measured. Histological features of the colon were also analyzed. Results: Supplementing the TNBS-induced group with the plant extracts suppressed oxidative stress, enhanced cytoprotective antioxidants, and reduced inflammation. The histological evaluation also showed restoration of damaged tissues. Conclusion: Our findings indicate the curative ability of the hydroalcoholic Carthamus tinctorius L. extracts and can be a good therapeutic candidate to treat Ulcerative colitis. Keywords: Ulcerative colitis, TNBS, Carthamus tinctorius L., Oxidative stress, Inflammation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17616 |
| Co-Author | Niu, Zhongbao |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-780.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-26 | 2022-1388 | 2022-08-26 | 2022-08-26 | Articles Abstract Database |