Pazopanib colon targeted liposomal drug delivery for colorectal cancer: high-pressure homogenization process optimization and In-vivo evaluation (Record no. 17355)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220829105134.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220829b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17647 |
| Author | Lahoti, Swaroop |
| 245 ## - TITLE STATEMENT | |
| Title | Pazopanib colon targeted liposomal drug delivery for colorectal cancer: high-pressure homogenization process optimization and In-vivo evaluation |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 387-395p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Pazopanib is second-generation tyrosinekinase inhibitor used in Colorectal cancer (CRC) which is effective orally. Targeted liposomal drug delivery will reduce the unwanted side effects of the drug. The application of High-pressure homogenizers for the preparation of systems like liposomes and lipid dispersions is rising because of its ability of vesicle disruption. Aim: Major objective of present research work was to optimize high pressure homogenization process for formulation of colon targeted liposomal drug delivery system of Pazopanib and its in-vivo evaluation. To study the influence of homogenization Pressure and number of cycles on some parameters, such as vesicle size and polydispersity index (PDI). Materials and Methods: The liposomes were formulated with HSPC (Hydrogenated Phosphotidylcholin from Soybean) m-PEG DSPE-2000 (Phospolipid) and Cholesterol using Ethanol injection method followed by downsizing by EmilsiFlex High pressure Homogenizer. Results and Conclusion: The liposomes were evaluated for entrapment efficiency, in-vitro drug release, osmolality, particle size, size distribution, polydispersity index, FEG-SEM and stability studies. Optimization studies concluded that the optimized formulation with homogenization pressure of 1000, 1500, 2000 psi and number of cycle 9, 6, 6 respectivly gives particle size of 109 nm with PDI 0.998 and desirability 0.975. In-vivo studies in wrister rats in which carcino genesis was done using 1,2- dimethylhydrazine (DMH), indicated that Pazopanib liposomes caused significant tumors growth suppression in terms of tumor volume and weight as compared to control. Histo-pathological evaluation showed that the animals treated with pazopanib liposomes had moderate dysplasia where as untreated animals had severe dysplasia. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17648 |
| Co-Author | Mukesh Kumar |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-387.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-29 | 2022-1422 | 2022-08-29 | 2022-08-29 | Articles Abstract Database |