Evaluation of anticancer potential of mimosa diplotricha ethanolic leaf extract on N-methyl-N- nitroso urea induced colorectal carcinogenesis in wistar albino rats (Record no. 17366)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830095408.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17668 |
| Author | Madathil, Sri Rashmy |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of anticancer potential of mimosa diplotricha ethanolic leaf extract on N-methyl-N- nitroso urea induced colorectal carcinogenesis in wistar albino rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 479-488p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Colorectal Cancer, (CRC) ranks third among global cancer incidence statistics and occupies fourth position as far as cancer related death is concerned and the aim of the study is to evaluate the therapeutic potential of Mimosa diplotricha ethanolic leaf extract in chemically induced colorectal carcinogenesis in Wistar albino rats. Materials and Methods: CRC was induced by intrarectal instillation of N-Methyl-N-Nitrosourea (MNU), 2mg per rat in 0.5ml of distilled water three times a week for five weeks. Rats were grouped as control, induced, induced and standard drug treated (15mg/kg.bw), induced and plant extract treated (in two doses 200mg/kg.bw and 400mg/kg.bw) and normal rats with respective plant extract treatment (200mg/kg.bw and 400mg/kg.bw). Treatment were carried out for 60 days followed which animals were euthanized and serum markers, oxidative stress, microbial enzymatic, histological and immunohistochemical parameters were analysed. Results: M. diplotricha was found to be effective in the down regulation of serum inflammatory and tumour markers like tumour necrosis factor alpha, transforming growth factor beta, carcinoembryogenic antigen and colon cancer specific antigen-4 levels. Oxidative stress parameters and histological data also supported the therapeutic efficacy of M. diplotricha. Expression of anti-apoptotic protein Bcl-2 was also found be downregulated in induced animals treated with M. diplotricha as evident from immunohistochemical data. Conclusion: The results of present research suggest that M. diplotricha ethanolic leaf extract showed a significant therapeutic potential against chemically induced colorectal carcinogenesis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17669 |
| Co-Author | Kannappan, Poornima |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-479.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-30 | 2022-1433 | 2022-08-30 | 2022-08-30 | Articles Abstract Database |