Development of tapentadol hydrochloride loaded proniosomal gel using main effects screening design and in silico verification using parameter sensitivity analysis (Record no. 17597)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922120051.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18031 |
| Author | Sangeetha G. |
| 245 ## - TITLE STATEMENT | |
| Title | Development of tapentadol hydrochloride loaded proniosomal gel using main effects screening design and in silico verification using parameter sensitivity analysis |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 65-76p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: Tapentadol Hydrochloride is a centrally acting opioid analgesic of biopharmaceutical classification system class I drug. Oral administration of tapentadol hydrochloride undergoes extensive first-pass metabolism leads to poor bioavailability. The present study was aimed to screen the critical material attributes to deliver the tapentadol hydrochloride through the transdermal route using a carrier proniosomal gel. Methodology: Main effect screening design has been constructed to screen the choice of surfactant used for the formulation of tapentadol hydrochloride proniosomal gel. The critical material attributes selected were surfactant, cholesterol, and soya lecithin, with responses entrapment efficiency (%), vesicle size (nm), and zeta potential (mV). All 24 runs of experiments were performed and evaluated to check the model fit. The in silico verification was analyzed using parameter sensitivity analysis. Results: The prediction profiler showed maximum desirability for Kolliphore RH 40 against the set goals. The design diagnostic efficiency was measured better for the constructed MESD. Also, parameter sensitivity analysis confirms that the vesicle size would play a principal role in the permeation of tapentadol hydrochloride proniosomal gel. Conclusion: Hence, Kolliphore RH 40 was considered for the further optimization process. The tapentadol hydrochloride proniosomal gel would be a better alternative to oral therapy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18032 |
| Co-Author | Swamivel Manickam, M. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-65_0.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-09-22 | 2022-1699 | 2022-09-22 | 2022-09-22 | Articles Abstract Database |