Fabrication and evaluation of gemcitabine-loaded alginate microspheres: a potential approach for treatment of various carcinomas (Record no. 17600)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922123257.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18035 |
| Author | Maruf Hossain |
| 245 ## - TITLE STATEMENT | |
| Title | Fabrication and evaluation of gemcitabine-loaded alginate microspheres: a potential approach for treatment of various carcinomas |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 86-93p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim/background: Microspheres are spherical particles, having a core, having a particle size of 1μm to 1000μm. They are advantageous as compared to conventional dosage forms of drugs, in parameters like sustainability and control of drug release, drug protection, biodegradability, targeting ability and many more. Gemcitabine is a prodrug and is used in various carcinomas. Sodium Alginate and Ethyl Cellulose are used as polymers. The fabrication aims to sustain the drug release which can treat pancreatic, breast, ovarian and lung cancer. Materials and Methods: Microspheres have been made by Ionotropic Gelation method, Sodium alginate, Ethyl cellulose and Calcium chloride. Weighed quantity of drug and polymer were added to sodium alginate solution, which was then added drop wise to Calcium chloride solution under continuous stirring to procure spherical rigid microspheres. These were then subjected to various physicochemical characterizations and surface analysis. Results and Conclusion: Results have shown that by increasing the polymer concentration, entrapment efficiency and drug loading have also increased. Particle size, SEM and micromeritic evaluation have exhibited satisfactory results. The drug release studies depict that most of the batches have showed less than 10% release acid media so it protects the drug from the upper part of GI Tract. These attributes prove that microsphere technology, being a crucial novel drug delivery system can be very effective in reducing dose frequency, dose dumping and better patient compliance. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18036 |
| Co-Author | Chatterjee, Shayeri |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-86.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-09-22 | 2022-1702 | 2022-09-22 | 2022-09-22 | Articles Abstract Database |