Formulation and evaluation of natamycin solid dispersion incorporated ophthalmic films (Record no. 17603)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922144147.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18040 |
| Author | Bhandari, Lavanya |
| 245 ## - TITLE STATEMENT | |
| Title | Formulation and evaluation of natamycin solid dispersion incorporated ophthalmic films |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 103-111p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The aim of this study was to enhance the solubility of Natamycin, an anti- fungal agent used in fungal keratitis, through solid dispersion incorporated ophthalmic films with the purpose to avoid frequent dosing, enhance the period of retention, and sustaining release for better patient compliance. Materials and Methods: Firstly, solid dispersions were prepared by the solvent evaporation method and then, the best solid dispersion formulation was incorporated into films which were prepared by the solvent casting method using retarding polymers Ethyl cellulose, PVA and Chitosan. PEG-400 was used as a plasticizer. The films were evaluated for their thickness, surface pH, drug content, weight uniformity, folding endurance, tensile strength, antimicrobial activity, in-vitro and ex-vivo permeation studies, and in-vitro antifungal studies. Results and Discussion: The films exhibited good mechanical properties with promising results and were in an acceptable range. The optimized formulation NF6 shows more drug release in in-vitro studies as compared to ex-vivo. This is due to the varying pore size of the cornea and disturbance of other tissues. An ocular irritation test revealed that the prepared formulation was non-irritant. Conclusion: Thus, the formulated ophthalmic film seems to be a promising formulation for the safe and effective delivery of Natamycin through the ocular route in the treatment of fungal keratitis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18041 |
| Co-Author | Patil, Archana S. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-103_2.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-09-22 | 2022-1705 | 2022-09-22 | 2022-09-22 | Articles Abstract Database |