Effect of ocimum sanctum in sodium fluoride (NaF) induced fluorosis in rats: a study with respect to antioxidant enzymes and fluorosis markers (Record no. 17617)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220923095839.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18063 |
| Author | Shanmugam, Kondeti Ramudu |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of ocimum sanctum in sodium fluoride (NaF) induced fluorosis in rats: a study with respect to antioxidant enzymes and fluorosis markers |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 175-183p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Fluoride contamination was observed in groundwater’s of India, Pakistan, China, Indonesia and several other countries. In India the states like Andhra Pradesh, Telangana, Rajasthan, Haryana etc are contaminated with fluoride. Approximately 68 million people are suffering from fluorosis in India. The current study was done to know the antioxidant effect, anti-fluorosis and free radical scavenging property of Ocimum sanctum (OS). Methods: Superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), glutathione reductase (GR), glutathione-s-transferase (GST), catalase (CAT), malondialdehyde (MDA), alanine aminotransferase (AAT), alkaline phosphatase (ALKP), aspartate aminotransferase (AST) and flurosis markers phosphorus (P4 ) and calcium (Ca) are estimated in all groups. 1,1-diphenyl-2-picryl hydrazyl radical (DPPH), hydroxyl radical, hydrogen peroxide (H 2O2 ), Gas chromatography–mass spectrometry (GC-MS) was analyzed in methanolic extract of Ocimum sanctum. Results: SOD, GR, GSH, GPx CAT, activities and Ca levels are decreased in sodium fluoride (NaF) intoxicated rats. Whereas MDA, ALKP AST, AAT, and P4 levels are increased in NaF rats. However, Ocimum phenolic fraction treatment normalized the antioxidant enzymes, hepatic markers and flurosis markers in NaF intoxicated rats. DPPH, H 2O2 and hydroxyl radical of ocimum posses potent free radical scavenging activities. GC – MS studies of Ocimum sanctum showed the presence of many bioactive compounds like Caryophyllene oxide, 2-(2-Propenyl)-m-anisidine, 2H-Pyan-2-one, 5,6-Dihydro-4-(2-methyl-3-methylene- 1-buten-4-yl etc. Further, histopathological observations prove that ocimum protects the hepatic tissue from NaF intoxication. Conclusion: Our study proves that Ocimum sanctum phenolic fraction protects the hepatic tissue from Na F induced fluorosis in rats. Key words: Ocimum sanctum, Antioxidant Enzymes, Fluorosis markers, Liver markers, GC-MS analysis, Rats. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18064 |
| Co-Author | Shanmugam, Bhasha |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-175.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-09-23 | 2022-1714 | 2022-09-23 | 2022-09-23 | Articles Abstract Database |