Enhanced antibacterial effect by antibiotic-loaded nanoparticles: A new strategy for battling bacterial resistance against Neisseria gonorrhoeae (Record no. 18424)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221207115315.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221207b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19351 |
| Author | Maharjan, Manima |
| 245 ## - TITLE STATEMENT | |
| Title | Enhanced antibacterial effect by antibiotic-loaded nanoparticles: A new strategy for battling bacterial resistance against Neisseria gonorrhoeae |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.16(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | BRNSS Publication Hub. |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 251-261p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: The recent reoccurrence of gonorrhea in the developed countries has been followed by rise and spread of gonococcal resistance to fluoroquinolones. The current research is aimed to prolong the contact time of antibiotics to the surface of the micro-organisms through the formulation of antibiotic-loaded nanoparticles. Methods: Ionotropic gelation method was used for the preparation of ciprofloxacin-loaded chitosan nanoparticles. The effect of various factors, including concentration of chitosan, sodium tripolyphosphate (TPP) on the different parameters such as entrapment efficiency, loading efficiency, and drug release was studied. Surface morphology, particle size, and antimicrobial studies, that is, zone of inhibition and minimum inhibitory concentration were also assessed. Results: The particles prepared under optimal condition of 1.77% Chitosan and 0.2% Sodium TPP had 96.23nm with polydispersivity index 1. In these particles with 1:1.5 Ciprofloxacin hydrochloride to chitosan, the entrapment efficiency, and loading efficiency were found to be 74.59% and 78.95%, respectively, with in vitro drug release of 10.23% in 24 h. Conclusion: The developed ciprofloxacin hydrochloride-loaded chitosan nanoparticles were found to exhibit effective antimicrobial activity against Neisseria gonorrhoeae, which showed high resistance toward conventional dosage forms. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 11945 |
| Co-Author | Baby, Beny |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of green pharmacy |
| International Standard Serial Number | 0973-8258 |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.greenpharmacy.info/index.php/ijgp/article/view/3301/1243 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-12-07 | 2022-2295 | 2022-12-07 | 2022-12-07 | Articles Abstract Database |