Co-administration of coenzyme Q10 and HMG-CoA reductase inhibitor attenuates oxidative stress, TGF-β, TNF-α, nitrite content and MPO levels against experimentally-induced diabetic nephropathy in rats (Record no. 18663)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230112150949.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230112b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19678 |
| Author | Maheshwari, Rajesh A. |
| 245 ## - TITLE STATEMENT | |
| Title | Co-administration of coenzyme Q10 and HMG-CoA reductase inhibitor attenuates oxidative stress, TGF-β, TNF-α, nitrite content and MPO levels against experimentally-induced diabetic nephropathy in rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1091-1098p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: Diabetes is a major disease that causes a tremendous economic burden internationally. To tackle this horrible condition, good therapeutic intervention with nutraceutical is required. These include diabetic nephropathy, which ranges from chronic kidney disease to end-stage renal failure. Thus, this study used nutraceutical such coenzyme Q10 and HMG-CoA reductase inhibitor (rosuvastatin) to see how beneficial they are in treating diabetic nephropathy. Materials and Methods: The animal experiments were conducted to induce nephropathy by using streptozotocin-nicotinamide. Animals were divided into five groups such as control, diabetic control, coenzyme Q10, rosuvastatin and their combination. The renal function test was conducted by estimating uric acid, creatinine and urea. Antioxidant parameters were assessed by evaluating MDA, SOD, GSH and catalase activity in renal tissue. Levels of MPO, TGF-β, TNF-α and nitrite concentration were measured together with alterations in histopathology in the kidneys were observed in every treated animal. Results: Diabetic rats were studied for signs of nephropathy, and the results showed elevated levels of urea, creatinine, uric acid, MPO activity, TGF-β, TNF-α, nitrite and MDA as well as decreased levels of GSH, SOD and CAT activity. It was shown that when coenzyme Q10 and rosuvastatin were given combined, renal function tests improved far more quickly than when the two medications were given separately. Conclusion: This study found that combination therapy improved renal function and controlled free radical production, inflammatory mediators, and histological alterations that lead to kidney injury. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15893 |
| Co-Author | Sen, Ashim Kumar |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-4-1091.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2023-01-12 | 2023-0106 | 2023-01-12 | 2023-01-12 | Articles Abstract Database |