000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20230204150409.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
230204b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
19887 |
Author |
Anila, L. |
245 ## - TITLE STATEMENT |
Title |
In vitroantiplatelet activity of an isoflavanone isolated from methanolic extract of emblica officinalis fruits |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol.14(11) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
M P |
Name of publisher, distributor, etc. |
Innovare Academic Sciences Pvt Ltd |
Year |
2022 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
48-53p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Objective: In this study, we aimed to isolate a polyphenolic compound from a polyphenolic-rich fraction from Emblica officinalis fruits and also study its effect on adenosine diphosphate (ADP) and collagen-induced in vitro platelet aggregation.Methods: The polyphenolic-rich fraction was prepared by 80% methanolic extraction. The residue was extracted successively with hexane, benzene, ethyl acetate and n-butanol. Ethyl acetate residue was selected for column chromatography because of its high polyphenolic content. It was subjected to repeated column chromatography of series with different eluents of increasing polarity. A brown amorphous powder was obtained from ethyl acetate: methanol (7:3) fraction. This sample was subjected to UV-visible spectrum, IR spectrum, 1H NMR, 13C NMR and electrospray mass spectrum (ES-MS) studies for its structural elucidation.Results: A compound, 5, 7, 4'-trihydroxy 3'-methoxy isoflavanone was identified from polyphenolic rich ethyl acetate: methanol (7:3) fraction separated from the 80% methanolic extract of Embica officinalis fruits by repeated column chromatography. Yield of the compound was 421.05 mg/kg. This compound exhibited antiplatelet activity well comparable with that of quercetin.Conclusion: The present study proved thatthe isolated compound5, 7, 4'-trihydroxy 3'-methoxy isoflavanone exerts a significant inhibitory activityon ADP and collagen-induced in vitro platelet aggregation, which can be considered as an effective remedy for alleviating complications of cardiovascular diseases. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
19888 |
Co-Author |
Hashim, M. S. |
773 0# - HOST ITEM ENTRY |
Title |
International journal of pharmacy and pharmaceutical science |
International Standard Serial Number |
2656-0097 |
Place, publisher, and date of publication |
Bhopal Innovare Academic Sciences Pvt Ltd |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
https://innovareacademics.in/journals/index.php/ijpps/article/view/46212/27140 |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |