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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20230320122722.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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230320b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
20172 |
| Author |
Mehta, Binny |
| 245 ## - TITLE STATEMENT |
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| Title |
Chemometric assisted spectrophotometric method for the simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in bulk and tablet dosage form |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.84(3), May-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
669-675p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
In this work, a numerical method, based on the use of spectrophotometric data coupled to partial least squares, multivariate calibration is evaluated for the simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in bulk and tablet dosage form. Tablet Olmetor-H (HTZ 12.5 mg and OLM 20.0 mg) was used in this study. The equipment used was a Ultraviolet-Visible double beam spectrophotometer with a matching pair of 1 cm quartz cell and electronic balance. Spectra of olmesartan medoxomil and hydrochlorothiazide were recorded at concentrations within their linear ranges 2.5-20 μg/ml and 4-32 μg/ ml, respectively and were used to compute a total of 25 synthetic mixtures involving 16 calibration and 9 validation sets between the wavelength range of 200 nm and 350 nm with the wavelengths intervals, lambda=3 nm in methanol. The analytical performances of these chemometric methods were characterized by relative prediction errors and recovery studies (%), and were compared with each other. The proposed method is simple, rapid and can be easily used as an alternative analysis tool in the quality control of drugs and formulation. PLS was applied successfully for the simultaneous determination of OLM and HTZ in laboratory mixtures and pharmaceutical formulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
11157 |
| Co-Author |
Joshi H. |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
0250-474X |
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| Title |
Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijpsonline.com/articles/chemometric-assisted-spectrophotometric-method-for-the-simultaneous-determination-of-olmesartan-medoxomil-and-hydrochlorothiazide-4630.html |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
