| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20230412114048.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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230412b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15542 |
| Author |
Mallikarjun, G. |
| 245 ## - TITLE STATEMENT |
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| Title |
Synthesis of curcumin based imidazo[2,1-b]thiazole derivatives and their biological evaluation as antiproliferative agents |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.61, Jan |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
New Delhi |
| Name of publisher, distributor, etc. |
CSIR |
| Year |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
13-20p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Motivated by the antiproliferative potential of curcumin and imidazothiazoles, a series of curcumin based imidazo[2,1-b] thiazole derivatives have been prepared, characterized and evaluated for their anticancer activity against various human cancer cell lines. These synthesized compounds have been found to have appreciable to moderate activity. Consequently, compounds 8a and 8g display noteworthy cytotoxicity with IC50 values of 7.2 μM and 4.7 μM, respectively, against A549 cell line. Furthermore, compounds 8a, 8b and 8g exhibit substantial cytotoxicity with IC50 values ranging between 9.1 μM to 9.9 μM respectively, against HeLa cell line. Interestingly, compounds 8a and 8g exhibit appreciable cytotoxicity with IC50 values ranging between 7.5 μM to 8.7 μM respectively, against DU145 cancer cell line. Overall, four compunds (8a, 8b, 8g and 8h) demonstrate IC50 values less than 10 μM against selected human cancer cell lines. They could be taken further for investigation of their mode of action and other parameters.
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| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
5009 |
| Topical term or geographic name entry element |
GENERAL CHEMISTRY |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15546 |
| Co-Author |
Krishnam Raju, A. |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Indian journal of chemistry (Section B) |
| Place, publisher, and date of publication |
New Delhi NISCAIR-CSIR 2005 |
| International Standard Serial Number |
0019-5103 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
http://op.niscpr.res.in/index.php/IJC/article/view/60046 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
