| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20230427094417.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
230427b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
20571 |
| Author |
Umarani, W. A. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Discovery of selective and potent anti-tubercular activity in arylpentane-1,4-diones |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.61(4), Apr |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
New Delhi |
| Name of publisher, distributor, etc. |
CSIR |
| Year |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
411-415p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Anti-tubercular activity (MIC 50µg/mL against Mtb H37Rv) have been reported in hispolons, which possess α, β-unsaturated-1,3-diketone functional group. In the pursuit to optimize structure and bioactivity, various substituted arylpentane-1,4-diones S1-8 have been synthesised. Upon screening, the test compounds show negligible antimicrobial activity against the tested organisms at 100 µg/mL but show antitubercular activity against Mycobacterium tuberculosis H37Rv strain with an MIC 0.8 to 25µg/mL. Compounds having a halogen at the ortho position on the aromatic ring show highest potency (MIC 0.8µg/mL), implying a relation between the position of the halogen atom and anti-tubercular activity. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
5009 |
| Topical term or geographic name entry element |
GENERAL CHEMISTRY |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
20572 |
| Co-Author |
Sony, K. P. |
| 773 0# - HOST ITEM ENTRY |
|---|
| International Standard Serial Number |
0019-5103 |
| Place, publisher, and date of publication |
New Delhi NISCAIR-CSIR 2005 |
| Title |
Indian journal of chemistry (Section B) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
http://op.niscpr.res.in/index.php/IJC/article/view/62561 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
