1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as antibacterial and anticancer agents (Record no. 19241)

000 -LEADER
fixed length control field a
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20230427102618.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 230427b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 20580
Author Vatsal, Manu
245 ## - TITLE STATEMENT
Title 1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as antibacterial and anticancer agents
250 ## - EDITION STATEMENT
Volume, Issue number Vol.61(4), Apr
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. New Delhi
Name of publisher, distributor, etc. CSIR
Year 2022
300 ## - PHYSICAL DESCRIPTION
Pagination 442-449p.
520 ## - SUMMARY, ETC.
Summary, etc. The new 1,5-disubstituted 9,10 anthraquninone compounds have been synthesized and characterized by FT-IR, 1H and 13C NMR, and mass spectrometry. Mass fragmentation pattern confirms the structure of the synthesized analogues. The synthesized compounds (B1-B5) have been found active against Hela (cervix carcinoma), prostate cancer and breast cancer cell lines in comparison to mitoxantrone. B2 screened out to be best. IC50 value of B2 and mitoxantrone against Hela cell lines have been observed to be 17μg/mL and 2.5μg/mL respectively. DNA intercalation has been proposed as per cell cycle analysis of B2 on Hela cell lines which show major alteration in G0/G1 and S phase. The results are further supported by molecular docking study of (B1-B5) compounds and mitoxantrone with quadruplex terminals i-motif. The compounds have also been evaluated for antibacterial activities.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 5009
Topical term or geographic name entry element GENERAL CHEMISTRY
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 20581
Co-Author Sharma, Anjali
773 0# - HOST ITEM ENTRY
International Standard Serial Number 0019-5103
Place, publisher, and date of publication New Delhi NISCAIR-CSIR 2005
Title Indian journal of chemistry (Section B)
856 ## - ELECTRONIC LOCATION AND ACCESS
URL http://op.niscpr.res.in/index.php/IJC/article/view/62579
Link text Click here
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type Articles Abstract Database
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Barcode Date last seen Price effective from Koha item type
          School of Pharmacy School of Pharmacy Archieval Section 2023-04-27 2023-0732 2023-04-27 2023-04-27 Articles Abstract Database
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