| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20230428113705.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
230428b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15679 |
| Author |
Deohate, Pradip P. |
| 245 ## - TITLE STATEMENT |
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| Title |
Synthesis of pyrimidine linked heterocyclic scaffolds by intramolecular cyclization and study of biological potential |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.61(5), May |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
New Delhi |
| Name of publisher, distributor, etc. |
CSIR |
| Year |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
551-557p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Synthesis of some interesting pyrimidine linked heterocyclic scaffolds by intramolecular cyclization has been worked out. Initially compound (4,6-dimethyl-pyrimidin-2-yl-amino)-acetic acid hydrazide has been prepared by reacting 2-amino-4,6-dimethyl pyrimidine with ethyl chloroacetate, followed by condensation with hydrazine hydrate. It has then been treated with N-aryl/alkyl isothiocyanates, followed by intramolecular cyclization using alkaline ethanolic solution of I2 with KI, o-phosphoric acid and aqueous KOH to afford respective heterocyclic compounds with differently substituted pharmacophores viz. (5-aryl/alkyl-amino-[1,3,4]-oxadiazol-2-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines, (5-aryl/alkyl-amino-[1,3,4]-thiadiazol-2-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines and (4-aryl/alkyl-5-mercapto-[1,2,4]-triazol-3-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines. Developments during the synthesis have been monitored by TLC. Constitution of synthesized compounds have been delineated in accordance with equivalent weight, elemental assay,chemical transformation and IR, 1H NMR and mass spectral investigations. Title compounds have been tested for their biological potential. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
5009 |
| Topical term or geographic name entry element |
GENERAL CHEMISTRY |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15677 |
| Co-Author |
Palaspagar, Kalpana A. |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Indian journal of chemistry (Section B) |
| International Standard Serial Number |
0019-5103 |
| Place, publisher, and date of publication |
New Delhi NISCAIR-CSIR 2005 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
http://op.niscpr.res.in/index.php/IJC/article/view/63648 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
