Homocysteine levels and clinical outcomes in schizophrenia—a pilot randomized controlled trial (Record no. 19480)
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| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230530164735.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230530b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 21016 |
| Author | Vedam, Venkata Aksheena Varahi |
| 245 ## - TITLE STATEMENT | |
| Title | Homocysteine levels and clinical outcomes in schizophrenia—a pilot randomized controlled trial |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.13(3), Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | New Delhi |
| Name of publisher, distributor, etc. | SAGE |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 284-292p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives:To find out the relation between homocysteine levels in peripheral blood and the effectiveness as well as the safety of haloperidol and olanzapine in schizophrenia treatment. Materials and Methods:A prospective randomized parallel-group open-label interventional clinical trial was conducted on 40 mild to moderate schizophrenia patients. To compare the efficacy of olanzapine and haloperidol Brief Psychiatric Rating Scale (BPRS) score was used. Homocysteine levels of peripheral blood and Abnormal Involuntary Movement Scale scores were evaluated. Results:BPRS score improved in both groups on day 14 and day 28. But significantly more with olanzapine (P value =.001). The olanzapine group showed a higher reduction (13.91±0.47 to 9.74±0.5) in homocysteine levels than the haloperidol group. Also, the BPRS scores negatively correlated (r = –0.66) to homocysteine levels. Conclusion:Therefore, our study shows that peripheral blood homocysteine levels can be used to predict and assess the treatment outcome in schizophrenia patients. Biomarker driven approach in schizophrenia will allow the patients to be treated promptly with the right drug. In this light, personalized treatment holds great potential in the future. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 21017 |
| Co-Author | Ghanta, Mohan Krishna |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0976-500X |
| Title | Journal of pharmacology and pharmacotherapeutics |
| Place, publisher, and date of publication | New Delhi SAGE Publications |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://journals.sagepub.com/doi/epub/10.1177/0976500X221128649 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2023-05-30 | 2023-0897 | 2023-05-30 | 2023-05-30 | Articles Abstract Database |