Optimized solvents for the maceration of phenolic antioxidants from curcuma xanthorrhiza rhizome using a simplex centroid design (Record no. 19675)

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005 - DATE AND TIME OF LATEST TRANSACTION
control field 20230804094930.0
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fixed length control field 230804b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 21404
Author Nurcholis, Waras
245 ## - TITLE STATEMENT
Title Optimized solvents for the maceration of phenolic antioxidants from curcuma xanthorrhiza rhizome using a simplex centroid design
250 ## - EDITION STATEMENT
Volume, Issue number Vol.15(1), Jan-Mar
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mumbai
Name of publisher, distributor, etc. Wolter Kluwer
Year 2023
300 ## - PHYSICAL DESCRIPTION
Pagination 35-41p.
520 ## - SUMMARY, ETC.
Summary, etc. Curcuma xanthorrhiza Roxb., from the Zingiberaceae family, is a famous plant native to Indonesia that is highly effective in treating diseases due to the various chemical compounds it contains.
Objective:

This study aims to optimize the extraction process for the phenolic content, with its antioxidant activity, from the rhizome of C. xanthorrhiza using different solvent (water, acetone, methanol, and ethanol) systems based on the simplex centroid design using the Design Expert 13.0 program.
Methods and Material:

Total phenolic content (TPC) was analyzed by colorimetry using Follin–Ciocalteu, while the antioxidant activity was measured based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) using a spectrophotometer.
Results:

To measure TPC and DPPH, a special cubic model was used; to measure FRAP, a linear model was utilized. Each model demonstrated a good match with the R2 values for TPC (0.9808), DPPH (0.9583), and FRAP (0.7872). The combination of a mixture of water (0.409), acetone (0.307), and methanol (0.284) with a desirability level of 0.723, resulted in a TPC of 34.112 mg gallic acid equivalent (GAE)/g dry weight (DW), DPPH of 26.533 μmol Trolox equivalent (TE)/g DW, and FRAP of 92.353 μmol TE/g DW. This showed a high extraction efficiency which was optimal.
Conclusions:

The best condition to extract the rhizomes of C. xanthorrhiza was a ternary combination of solvents including water, acetone, and methanol in the proportions of 0.409, 0.307, and 0.284, respectively, with a desirability level of 0.723.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 21405
Co-Author Marliani, Nelly
773 0# - HOST ITEM ENTRY
International Standard Serial Number 0976-4879
Title Journal of pharmacy and bio allied science
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://journals.lww.com/jpbs/Fulltext/2023/15010/Optimized_Solvents_for_the_Maceration_of_Phenolic.6.aspx
Link text Click here
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Source of classification or shelving scheme
Koha item type Articles Abstract Database
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Barcode Date last seen Price effective from Koha item type
          School of Pharmacy School of Pharmacy Archieval Section 2023-08-04 2023-1086 2023-08-04 2023-08-04 Articles Abstract Database
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