Preparation and characterization of capsaicin encapsulated polymeric micelles and studies of synergism with nicotinic acids as potential anticancer nanomedicines (Record no. 20132)
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fixed length control field | a |
003 - CONTROL NUMBER IDENTIFIER | |
control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20231120120603.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 231120b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME | |
9 (RLIN) | 22126 |
Author | Rawan, Shamsheer |
245 ## - TITLE STATEMENT | |
Title | Preparation and characterization of capsaicin encapsulated polymeric micelles and studies of synergism with nicotinic acids as potential anticancer nanomedicines |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.15(3), Jul-Aug |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Mumbai |
Name of publisher, distributor, etc. | Wolter Kluwer |
Year | 2023 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 107-125p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Capsaicin micelles were prepared by the direct dissolution using the amphiphilic copolymer Pluronic P123 and advanced for substantially novel submicro-nanocytotoxicity. Results: Superior cytotoxicity of capsaicin loaded nanomicelles vs. both the raw capsaicin and reference cisplatin in pancreatic PANC1, breast MCF7, colorectal resistant CACO2, skin A375, lung A549 and prostate PC3 cancer cell lines were delineated. Nicotinic acid (NA) derivative 39 (2-Amino IsoNA) had antiinflammatory potential but consistently lacked antiproliferation in MCF7, PANC1 and CACO2. Besides NA derivatives 8 (5-MethylNA) and 44 (6-AminoNA) exhibited lack of antiinflammation but had comparable antitumorigenesis potency to cisplatin in PANC1 cells. Though capsaicin loaded nanomicelles exerted pronounced antiinflammation (with IC50 value of 510 nM vs. Indomethacin’s) in lipopolysacchride-induced inflammation of RAW247.6 macrophages; they lacked DPPH scavenging propensities. Free capsaicin proved more efficacious vs. its loaded nanocarriers to chemosensitize cytotoxicity of combinations with NAs 1(6-Hexyloxy Nicotinic Acid), 5(6-OctyloxyNA), 8(5-MethylNA), 12(6-Thien-2yl-NA), 13(5,6-DichloroNA) and 44(6-AminoNA) in CACO2, PANC1 and prostate PC3. Conclusion: Capsaicin loaded nanomicelles proved more efficacious vs. free capsaicin to chemo-sensitize antiproliferation of cotreatments with NA derivatives, 1, 5, 8, 12, 13 and 44 (in skin A375), 1, 5, 8 and 12 (in breast MCF7), and 1, 5, 12 and 44 (in lung A549). |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 5026 |
Topical term or geographic name entry element | PHARMACEUTICAL BIOTECHNOLOGY |
700 ## - ADDED ENTRY--PERSONAL NAME | |
9 (RLIN) | 22127 |
Co-Author | Sunoqrot, Suhair |
773 0# - HOST ITEM ENTRY | |
Title | Journal of pharmacy and bio allied science |
International Standard Serial Number | 0976-4879 |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
URL | https://journals.lww.com/jpbs/fulltext/2023/15030/preparation_and_characterization_of_capsaicin.2.aspx |
Link text | Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2023-11-20 | 2023-1573 | 2023-11-20 | 2023-11-20 | Articles Abstract Database |