| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20231205103905.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
231205b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
22301 |
| Author |
Adhao Vaibhav, S. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Development and validation of stability indicating high performance liquid chromatography method for determination of leflunomide |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.13(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Raipur |
| Name of publisher, distributor, etc. |
Asian Pharma Press |
| Year |
2023 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
93-98p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
A new simple, specific, accurate and precise RP-HPLC method was developed for determination of Leflunomide. In the present study, stress testing of Leflunomide was carried out according to ICH guidelines Q1A (R2). Leflunomide was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Effective separation of drug and degradant was achieved was achieved on a Hypersil BDS C18 column (250mm × 4.6mm, 5.0µ particle size) under specific stress conditions using acetonitrile – 0.02M ammonium acetate buffer (60: 40, v/v) as a solvent system with a flow rate of 1.0mL/min. Quantification and linearity was achieved at 260nm over the concentration range of 5-30µg/mL for Leflunomide. The investigated method was validated as per guidelines. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12265 |
| Co-Author |
Ambhore, Jaya P. |
| 773 0# - HOST ITEM ENTRY |
|---|
| International Standard Serial Number |
2231-5667 |
| Place, publisher, and date of publication |
Raipur A & V Publications |
| Title |
Asian journal of pharmaceutical analysis |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
https://ajpaonline.com/AbstractView.aspx?PID=2023-13-2-5 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
