Process optimization and evaluation of immediate release tablet containing benzimidazoles (Record no. 20351)

000 -LEADER
fixed length control field a
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20231218150350.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 231218b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 22458
Author Rao, N. Sudarshan
245 ## - TITLE STATEMENT
Title Process optimization and evaluation of immediate release tablet containing benzimidazoles
250 ## - EDITION STATEMENT
Volume, Issue number Vol.13(3), Jul-Sep
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Raipur
Name of publisher, distributor, etc. Asian Pharma Press
Year 2023
300 ## - PHYSICAL DESCRIPTION
Pagination 180-182p.
520 ## - SUMMARY, ETC.
Summary, etc. Olmesartan is an angiotensin II antagonist used in the treatment of hypertension. In present investigation an attempt was made to develop solid oral formulation of Olmesartan. The purpose of this study was to develop the formulation as immediate release tablet of Olmesartan by using excipients by design of experiment. Tablets were prepared by using direct compression method. In HPLC study of Olmesartan the correlation coefficient was found to be 0.993 at 296 nm at flow rate of 0.7 ml/min at injection volume of 5 ?L Tablets were evaluated for hardness, thickness, dissolution calibration study, drug content and all the in-vitro studies were performed using USP apparatus type II All in-vitro studies were carried out using Phosphate buffer at 37°C ± 0.5°C. The optimized formulation showed in- vitro drug release of 96. 80 % at the end of 60 min. Comparing to other ARB’s drug shows high affinity Angiotensin II type 1 (AT1) receptors has long duration of action. Olmesartan has longest half life of 24 hrs where, T max is 0.5 – 1 hr, and it was so rapidly achieving desired plasma concentrations. Stability studies were carried out according to ICH guidelines. All the results were obtained within given ICH limits.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 22459
Co-Author Budda, Leena
773 0# - HOST ITEM ENTRY
International Standard Serial Number 2231-5667
Place, publisher, and date of publication Raipur A & V Publications
Title Asian journal of pharmaceutical analysis
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://ajpaonline.com/AbstractView.aspx?PID=2023-13-3-5
Link text Click here
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type Articles Abstract Database
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Barcode Date last seen Price effective from Koha item type
          School of Pharmacy School of Pharmacy Archieval Section 2023-12-18 2023-1725 2023-12-18 2023-12-18 Articles Abstract Database
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