Extensive arm skin necrosis following administration of unfractionated heparin (Record no. 20614)

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fixed length control field 240118b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 22813
Author Firouzabadi, Dena
245 ## - TITLE STATEMENT
Title Extensive arm skin necrosis following administration of unfractionated heparin
250 ## - EDITION STATEMENT
Volume, Issue number Vol.55(5), Sep-Oct
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mumbai
Name of publisher, distributor, etc. Wolter Kluwer
Year 2023
300 ## - PHYSICAL DESCRIPTION
Pagination 332-334p.
520 ## - SUMMARY, ETC.
Summary, etc. Unfractionated heparin (UH), a commonly used anticoagulant, can rarely cause skin necrosis following heparin-induced thrombocytopenia (HIT). A 38-year-old female, a case of chronic inflammatory demyelinating polyneuropathy (CIDP) admitted to the neurology ward, developed extensive skin necrosis following a change in UH dose at the exact site of UH injection. A sudden fall in the platelet count was observed within 48 h of increasing the UH dose. Necrosis of the outer layer of the skin along with clot formation and inflammation in the inner layers was detected after histopathological evaluation. UH was discontinued, and rivaroxaban was started for the patient as soon as the complication was detected. The patient was discharged in good condition after completing treatment for CIDP without any need for surgical removal of the necrotic tissue. Extensive skin necrosis, as a result of HIT, requires immediate discontinuation of UH and substitution of a nonheparin-based anticoagulation treatment.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4774
Topical term or geographic name entry element PHARMACOLOGY
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 22814
Co-Author Petramfar, Peyman
773 0# - HOST ITEM ENTRY
Place, publisher, and date of publication Andheri - Mumbai Wolters Kluwer India Private Limited
Title Indian Journal of Pharmacology
International Standard Serial Number 0253-7613
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751520/?report=classic
Link text Click here
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Source of classification or shelving scheme
Koha item type Articles Abstract Database
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          School of Pharmacy School of Pharmacy Archieval Section 2024-01-18 2024-0083 2024-01-18 2024-01-18 Articles Abstract Database
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