Exploring neuroprotective potential of cissus quadrangularis plant extract in parkinson’s disease (Record no. 20666)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240223150004.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240223b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 22895 |
| Author | Chauhan, Ranjan |
| 245 ## - TITLE STATEMENT | |
| Title | Exploring neuroprotective potential of cissus quadrangularis plant extract in parkinson’s disease |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.17(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | BRNSS Publication Hub. |
| Year | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 242-250p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Parkinson’s disease (PD) caused due to neuroinflammation and oxidative stress associated with motor and non-motor complications. Neuroprotection strategies create a hope for patients. Natural products have been increasing the gain to have specific molecular or pharmacological activities that are likely to supply the development of neuroprotective agents against PD. Cissus quadrangularis constitutes all suitable physical and chemical properties and its ability to cross the blood–brain barrier making it a relevant candidate for the treatment of neuroprotection in PD. Materials and Methods: The stem part of the plant was extracted with distilled water and ethanol. The antiparkinson’s activity of both extracts of C. quadrangularis was evaluated using rotenoneinduced excitotoxicity model in zebrafish for 96 h resulting in alterations in swimming pattern measured through a video recording system. Further, cognitive improvement activity in PD of both extracts of plant was evaluated using reserpine-induced cognitive impairments in mice for 29 days. Biochemical parameters, that is, levels of catalase and glutathione (GSH) were analyzed using UV-visible spectrophotometer. Results: The aqueous extract of C. quadrangularis (AECQ) showed a significant and dose-dependent effect against rotenone-induced PD in adult zebrafish’s at a dose of 4 and 10 ?g/mL and cognitive improvement activity against reserpine-induced cognitive impairment in mice at a dose of 200 mg/kg and 500 mg/kg. The AECQ also showed a significant in vivo antioxidant potential by restoring the levels of catalase and GSH. The results of the present study demonstrate the potential antiparkinson’s properties of the aqueous extract. Conclusion: The result of the present study conclusively shows the Anti-Parkinson’s activity of C. quadrangularis and improved cognition in PD. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0973-8258 |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| Title | International journal of green pharmacy |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.greenpharmacy.info/index.php/ijgp/article/view/3476 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2024-02-23 | 2024-0187 | 2024-02-23 | 2024-02-23 | Articles Abstract Database |