| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20240227144258.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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240227b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
22920 |
| Author |
Kaur, Saini Navjot |
| 245 ## - TITLE STATEMENT |
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| Title |
Antidiabetic polyherbal capsule: formulation, evaluation and safety measurements |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.85(3), May-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2023 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
686-697p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
The well-known plant components for their anti-diabetic properties are Azadirachta indica leaves, Pterocarpus marsupium heartwood, Picrorhiza kurroa rhizomes and Withania coagulans berries and fruit coat. The current study's objective was to create a polyherbal dosage form and assess its effectiveness and stability. The various methanolic extracts of all four medicines were combined in the 1:1:1:1 ratios to create the polyherbal extract. Both in vitro antioxidant and in vitro antidiabetic activity of the extract were evaluated. For their preformulation investigations, a total of six polyherbal compositions were examined. Through Fourier transform infrared spectroscopic analysis, the phytochemicals present were identified. The medication was then put into capsules with a 0 size and evaluated for every aspect of a capsule. The stability of the most recent medicine was examined under diverse circumstances. The 2,2-diphenyl-1- picrylhydrazyl half maximal inhibitory concentration value for the polyherbal extract was 60.56 μg/ml indicating in vitro antioxidant activity. The anti-diabetic action was equivalent to the industry standard and dose-dependent, with an half maximal inhibitory concentration value of 59.82 μg/ml for inhibiting alpha-amylase and 67.28 μg/ml for inhibiting alpha-glucosidase. The polyherbal formulation 1 displayed the best flow qualities. According to Fourier transform infrared spectroscopic data, granules may include terpenes, tannins, phenols and flavonoids. In 30 min, the capsules with polyherbal formulation 1 had a 95.77 % cumulative drug release value. The capsules were discovered to be stable under many types of lighting, however they disintegrate above 70 % humidity and over 55°. As a result, it was discovered that the polyherbal capsules were stable and effective in treating hyperglycemia. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
22921 |
| Co-Author |
Sharma, S. |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
0250-474X |
| Title |
Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijpsonline.com/articles/antidiabetic-polyherbal-capsule-formulation-evaluation-and-safety-measurements-5002.html |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
