Amygdalin inhibits cell proliferation, migration and invasion in thyroid cancer by regulating circ WHSC1/miR-195-5p (Record no. 20690)

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005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240228121613.0
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fixed length control field 240228b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 22932
Author Zhang, Xicai
245 ## - TITLE STATEMENT
Title Amygdalin inhibits cell proliferation, migration and invasion in thyroid cancer by regulating circ WHSC1/miR-195-5p
250 ## - EDITION STATEMENT
Volume, Issue number Vol.85(3), May-Jun
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mumbai
Name of publisher, distributor, etc. Indian Journal of Pharmaceutical Science
Year 2023
300 ## - PHYSICAL DESCRIPTION
Pagination 761-768p.
520 ## - SUMMARY, ETC.
Summary, etc. To probe the functions of amygdalin on thyroid cancer cells and further analyze whether its mechanism is related to regulating circWHSC1 and miR-195-5p expression. The relative levels of circWHSC1 and miR-195-5p in cells were analyzed by reverse transcription-quantitative polymerase chain reaction. Effects of amygdalin on thyroid cancer cell lines were calculated. Dual luciferase report assay was applied to ensure the targeting between circWHSC1 and miR-195-5p. The level of circWHSC1 was increased, while the level of miR-195-5p was declined in thyroid cancer tissues. Amygdalin treatment dose-dependently reduced cell viability, suppressed cell invasion, migration and colony formation abilities. Amygdalin treatment reduced the level of circWHSC1, as well as increased the level of miR-195-5p. CircWHSC1 directly bound to miR-195-5p. CircWHSC1 inhibition notably restrained cell growth and mobility in thyroid cancer. Moreover, circWHSC1 overexpression abated the suppressing functions of amygdalin on thyroid cancer cell proliferative, migratory and invasive abilities. Amygdalin inhibited cell proliferative, migratory and invasive abilities in thyroid cancer via circWHSC1/miR-195-5p axis.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 22933
Co-Author Lin, Shu
773 0# - HOST ITEM ENTRY
International Standard Serial Number 0250-474X
Title Indian journal of pharmaceutical sciences
Place, publisher, and date of publication New Delhi Indian Pharmaceutical Association
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URL https://www.ijpsonline.com/articles/amygdalin-inhibits-cell-proliferation-migration-and-invasion-in-thyroid-cancer-by-regulating-circwhsc1mir1955p-5019.html
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942 ## - ADDED ENTRY ELEMENTS (KOHA)
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Koha item type Articles Abstract Database
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          School of Pharmacy School of Pharmacy Archieval Section 2024-02-28 2024-0211 2024-02-28 2024-02-28 Articles Abstract Database
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