Relationship between vancomycin-induced nephrotoxicity and vancomycin trough concentration in older adults (Record no. 20822)
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control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20240401134629.0 |
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fixed length control field | 240401b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME | |
9 (RLIN) | 23133 |
Author | Dai, Ning |
245 ## - TITLE STATEMENT | |
Title | Relationship between vancomycin-induced nephrotoxicity and vancomycin trough concentration in older adults |
Remainder of title | :A retrospective observational study |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.55(3), May-Jun |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Mumbai |
Name of publisher, distributor, etc. | Wolter Kluwer |
Year | 2023 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 155-161p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | OBJECTIVES: The objective of the study is to investigate the risk factors of vancomycin-induced renal toxicity in older adults, especially in those with chronic kidney disease (CKD) Stages 3–5. METHODS: In this retrospective observational study, serum vancomycin trough concentrations (VTCs) in patients aged g65 years treated with vancomycin were analyzed, and independent risk factors of vancomycin-induced nephrotoxicity (VIN) were determined by logistic regression analysis. RESULTS: In total, 321 patients were included in this study. Serum VTC was an independent risk factor for vancomycin-induced renal toxicity in total cohort (odds ratio [OR], 1.07; P = 0.004) as well as in the cohort with CKD Stages 3–5 (OR, 1.09; P = 0.010). A daily dose of vancomycin and Charlson comorbidity index was an independent risk factor for vancomycin-induced renal toxicity in total cohort (OR, 3.63; P = 0.006) and in the cohort with CKD Stage 3–5 (OR, 1.83; P = 0.002), respectively. In older adults with CKD Stages 3a and 3b-5, the VTCs associated with higher risk for vancomycin-induced renal toxicity were 21.5 mg/L and 16.5 mg/L, respectively. CONCLUSIONS: In older adults, serum VTC is an independent risk factor for VIN. VTCs over 21.5 mg/L and 16.5 mg/L are associated with increased risk of VIN in this population with CKD Stage 3a and 3b-5, respectively. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4774 |
Topical term or geographic name entry element | PHARMACOLOGY |
700 ## - ADDED ENTRY--PERSONAL NAME | |
9 (RLIN) | 23134 |
Co-Author | Jiang, Chunyan |
773 0# - HOST ITEM ENTRY | |
International Standard Serial Number | 0253-7613 |
Title | Indian Journal of Pharmacology |
Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
URL | https://journals.lww.com/iphr/fulltext/2023/55030/relationship_between_vancomycin_induced.3.aspx |
Link text | Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2024-04-01 | 2024-0374 | 2024-04-01 | 2024-04-01 | Articles Abstract Database |