Mpacts of anthocyanin on apoptosis and toll-like receptor 4/cyclooxygenase 2/nuclear factor-kappa B signaling pathway in rats with spinal cord ischemia-reperfusion injury (Record no. 20845)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240404121851.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
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| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23171 |
| Author | Chen, Xueqiang |
| 245 ## - TITLE STATEMENT | |
| Title | Mpacts of anthocyanin on apoptosis and toll-like receptor 4/cyclooxygenase 2/nuclear factor-kappa B signaling pathway in rats with spinal cord ischemia-reperfusion injury |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.85(4), Jul-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 936-943p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To investigate the impact of anthocyanin on apoptosis of spinal cord ischemia-reperfusion injury rats and its regulation on Toll-like receptor 4/cyclooxygenase 2/nuclear factor-kappa B signaling pathway. Sixty healthy Sprague–Dawley rats were randomly separated into sham operation group, model group, anthocyanin low (50 mg/kg), medium (100 mg/kg), high (150 mg/kg) concentration groups, anthocyanin (150 mg/kg)+TAK-242 (10 mg/kg) group, 10 per group, administered at 72 h before surgery. After the experiment, the behavioral score after spinal cord injury was performed; blood was collected to separate serum, and the contents of interleukin-6, interleukin-1 beta and tumor necrosis factor alpha were measured; the rats were sacrificed to separate spinal cord tissue, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining was used to detect cell apoptosis, the expression of B-cell lymphoma protein 2-associated X was measured by immunohistochemistry, the expression of toll-like receptor 4, cyclooxygenase 2, p-nuclear factor-kappa B and nuclear factor-kappa B proteins was measured by Western blot. Compared with the sham operation group, the behavioral score and B-cell lymphoma protein 2-associated X expression in the model group were obviously decreased (p<0.05); the apoptosis index, serum interleukin-6, interleukin-1 beta, tumor necrosis factor alpha contents, B-cell lymphoma protein expression, toll-like receptor 4, cyclooxygenase 2 protein expression and p-nuclear factor-kappa B/nuclear factor-kappa B in spinal cord tissue were obviously increased (p<0.05). Compared with the model group, the behavioral scores and B-cell lymphoma protein 2-associated X expression in the anthocyanin low, medium and high concentration groups were obviously increased (p<0.05); the apoptosis index, serum interleukin-6, interleukin-1 beta, tumor necrosis factor alpha contents, B-cell lymphoma protein 2 expression, toll-like receptor 4, cyclooxygenase 2 protein expression and p-nuclear factor-kappa B/nuclear factor-kappa B in spinal cord tissue were gradually decreased (p<0.05). Compared with the anthocyanin high concentration group, the behavioral score and B-cell lymphoma protein 2-associated X expression in the anthocyanin+TAK-242 group were obviously increased (p<0.05); the apoptosis index, serum interleukin-6, interleukin-1 beta, tumor necrosis factor alpha contents, B-cell lymphoma protein 2 expression, toll-like receptor 4, cyclooxygenase 2 protein expression and p-nuclear factor-kappa B/nuclear factor-kappa B in spinal cord tissue were obviously decreased (p<0.05). Anthocyanin can ameliorate cell apoptosis in spinal cord ischemia-reperfusion injury rats by inhibiting the expression of toll-like receptor 4/cyclooxygenase 2/nuclear factor-kappa B signaling pathway. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23172 |
| Co-Author | Zhu, Jinkun |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| International Standard Serial Number | 0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/impacts-of-anthocyanin-on-apoptosis-and-tolllike-receptor-4cyclooxygenase-2nuclear-factorkappa-b-signaling-pathway-in-ra.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2024-04-04 | 2024-0403 | 2024-04-04 | 2024-04-04 | Articles Abstract Database |