Effects of propofol on oxidative stress injury and silent information regulator 1/forkhead box protein 1 pathway of kupffer cells (Record no. 20863)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240415120905.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240415b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23203 |
| Author | Wen, Jiali |
| 245 ## - TITLE STATEMENT | |
| Title | Effects of propofol on oxidative stress injury and silent information regulator 1/forkhead box protein 1 pathway of kupffer cells |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.85(4), Jul-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1110-1117p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To investigate the effect of propofol on oxidative stress injury and silent information regulator 1/forkhead box protein 1 pathway of Kupffer cells induced by hydrogen peroxide. Kupffer cells were cultured in vitro, cell injury model was established by hydrogen peroxide induction, and it was divided into three groups; hydrogen peroxide injury group (300 μmol·l-1), propofol low (12.5 μg.ml-1), propofol medium (25.0 μg.ml-1), and propofol high (50.0 μg·ml-1) groups, in addition, Kupffer cells without any treatment were normal control group. Compared with normal control group ((100.00±0.00) %, (98.19±2.48), (3.76±0.21) pg/ml, (2.46±0.25) ng/l, (2.47±0.16) pmol/mg, (1.01±0.09), (8.31±0.23), (1.03±0.08), (1.12±0.11), (2.18±0.13)), the Kupffer cell survival rate (56.24±2.12) %, tetramethylrhodamine ethyl ester fluorescence intensity (54.57±2.64), contents of superoxide dismutase (2.51±0.19) pg/ml, catalase (1.23±0.14) ng/l, glutathione peroxidase in cell supernatant (1.31±0.11) pmol/mg, silent information regulator 1 (0.21±0.02), forkhead box protein 1 messenger ribonucleic acid (0.99±0.03) and protein expressions [(0.19±0.02), (0.11±0.01)) decreased significantly in hydrogen peroxide group (p<0.05), and the content of malondialdehyde (4.56±0.37) mol/l in supernatant increased significantly (p<0.05); compared with hydrogen peroxide group, the Kupffer cell survival rate ((64.79±2.49) %, (72.62±2.53) %, (84.91±2.87) %), tetramethylrhodamine ethyl ester fluorescence intensity [(67.28±2.51), (80.65±2.64), (94.19±3.05)), contents of superoxide dismutase ((2.89±0.23) pg/ml, (3.24±0.15) pg/ml, (3.57±0.18) pg/ml), catalase ((1.57±0.18) ng/l, (1.88±0.19) ng/l, (2.23±0.17) ng/l), glutathione peroxidase in cell supernatant ((1.76±0.15) pmol/mg, (2.03±0.16) pmol/mg, (2.39±0.17) pmol/mg), silent information regulator 1 ((0.39±0.03), (0.52±0.04), (0.86±0.05)), forkhead box protein 1 messenger ribonucleic acid ((2.85±0.27), (4.11±0.22), (6.19±0.36)) and protein expressions (silent information regulator 1: (0.48±0.04), (0.71±0.06), (1.01±0.07)), (forkhead box protein 1: (0.45±0.06), (0.64±0.07), (0.87±0.09)) increased significantly in turn of propofol low group, propofol medium group and propofol high group (p<0.05), and the content of malondialdehyde ((4.18±0.35) mol/l, (3.62±0.14) mol/l, (2.87±0.17) mol/l) in supernatant decreased significantly in turn (p<0.05). Propofol can alleviate the oxidative stress injury of Kupffer cells induced by hydrogen peroxide and promote their survival, which may be related to the regulation of silent information regulator 1/forkhead box protein 1 pathway. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23204 |
| Co-Author | Gu, Shuhan |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| Title | Indian journal of pharmaceutical sciences |
| International Standard Serial Number | 0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/effects-of-propofol-on-oxidative-stress-injury-and-silent-information-regulator-1forkhead-box-protein-1-pathway-of-kupff.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2024-04-15 | 2024-0421 | 2024-04-15 | 2024-04-15 | Articles Abstract Database |