Pharmacokinetic study of zandopa® in rat model (Record no. 20870)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240416093949.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240416b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23216 |
| Author | Kolge, S. |
| 245 ## - TITLE STATEMENT | |
| Title | Pharmacokinetic study of zandopa® in rat model |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.85(4), Jul-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1163-1168p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The goal of this research is to examine the pharmacokinetics of Zandopa® in rats after oral administration of Zandopa® herbal formulation. Acclimatization of rats was done for 7 d before the study. The study consisted of 24 rats which had been separated equally into two groups i.e. vehicle control and Zandopa® control group with 12 animals in each group. The drug was administered via oral route in male Sprague Dawley rats. The vehicle control group rats were dosed with 1 % carboxymethyl cellulose and Zandopa® control group with 775 mg/kg of Zandopa® in 1 % carboxymethyl cellulose. Food was with-held for a further 1 h. The blood sample was taken between 0, 0.5, 1, 2, 4, 6, 8, 12 and 24 h time intervals after treatment with the respective drug. Plasma samples were prepared by centrifugation and concentration was measured by high performance liquid chromatography. Urine was collected at a time interval of 0-1, 1-4, 4-8, 8-24, 24-48 h after treatment with the respective drug, and kinetic parameters were measured. Then animals were sacrificed using isoflurane overdose and the liver was isolated and stored for metabolism study. The Cytochrome P-450 concentration and Cytochrome P-450 content was found to be 0.0012 mM and 1.2 nmol/mg/protein compared with the vehicle control group. The cumulative amount excreted was found to be 64.66 mg. The study of the pharmacokinetics of Zandopa® in rats was shown to be significant as compared to the vehicle control group. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20203 |
| Co-Author | Dhande, Swati |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| International Standard Serial Number | 0250-474X |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/pharmacokinetic-study-of-zandopasupsup-in-rat-model.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2024-04-16 | 2024-0428 | 2024-04-16 | 2024-04-16 | Articles Abstract Database |