Free radical scavenging activity of pleurotus ostreatus against ccl4-induced hepatic damage in wister rats (Record no. 20902)
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control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20240420143818.0 |
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fixed length control field | 240420b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME | |
9 (RLIN) | 23267 |
Author | Chandan, Lakkaraju |
245 ## - TITLE STATEMENT | |
Title | Free radical scavenging activity of pleurotus ostreatus against ccl4-induced hepatic damage in wister rats |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.15(12), Dec |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Bhopal |
Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
Year | 2023 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 17-22p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Objective: The present study was aimed to evaluate the anti-oxidant effect of Pleurotus ostreatus using in vitro and in vivo methodology. Methods: Methanolic extract of Pleurotus ostreatus (MEPO) was prepared by cold maceration technique. Rats weighing 150-200 g were divided into 6 groups of six each (n=6). Group I served as control (0.9% Nacl), group II was considered as the positive control, administered with CCl4 dissolved in olive oil (intraperitoneal injection at 0.5 mg/kg body weight), group III was given with CCl4+standard drug sylimarin (100 mg/kg body weight, p. o.), group IV, V and VI were administered with CCl4+MEPO at 200, 400 and 800 mg/kg orally for a period of 21 d. The liver injury was induced by the administration of CCl4 intraperitoneally with a single dose of CCl4 (0.5 mg/kg body weight) as a 1:1 (v/v) solution in olive oil. Results: In the Hydroxyl free radical scavenging assay, the IC50 values of the test extract was found to be 72.1±1.68 as compared with the standard drug (IC50-66.3±1.02), which was considered as significant (***p<0.001). In the reducing power assay, all the absorbance values were comparable to standard ascorbic acid and showed maximum reducing ability at the concentration of 500 µg/ml. In the in vivo anti-oxidant study, administration of MEPO to injury-induced rats at the dose of 400 and 800 mg/kg, significantly increased (**p<0.001) the levels of SOD and CAT, with a significant reduction in the MDA levels. Conclusion: The current study explored a potential source for anti-oxidants in the methanolic extract of Pleurotus ostreatus, thus seems to be protective to liver in CCl4-induced hepatic injury. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4639 |
Topical term or geographic name entry element | PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME | |
9 (RLIN) | 23268 |
Co-Author | Bhikshapathi, Darna |
773 0# - HOST ITEM ENTRY | |
Title | International journal of pharmacy and pharmaceutical science |
Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
International Standard Serial Number | 2656-0097 |
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URL | https://journals.innovareacademics.in/index.php/ijpps/article/view/49478 |
Link text | Click here |
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Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2024-04-20 | 2024-0460 | 2024-04-20 | 2024-04-20 | Articles Abstract Database |