Free radical scavenging activity of pleurotus ostreatus against ccl4-induced hepatic damage in wister rats (Record no. 20902)

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005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240420143818.0
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fixed length control field 240420b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 23267
Author Chandan, Lakkaraju
245 ## - TITLE STATEMENT
Title Free radical scavenging activity of pleurotus ostreatus against ccl4-induced hepatic damage in wister rats
250 ## - EDITION STATEMENT
Volume, Issue number Vol.15(12), Dec
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Bhopal
Name of publisher, distributor, etc. Innovare Academic Sciences Pvt Ltd
Year 2023
300 ## - PHYSICAL DESCRIPTION
Pagination 17-22p.
520 ## - SUMMARY, ETC.
Summary, etc. Objective: The present study was aimed to evaluate the anti-oxidant effect of Pleurotus ostreatus using in vitro and in vivo methodology.

Methods: Methanolic extract of Pleurotus ostreatus (MEPO) was prepared by cold maceration technique. Rats weighing 150-200 g were divided into 6 groups of six each (n=6). Group I served as control (0.9% Nacl), group II was considered as the positive control, administered with CCl4 dissolved in olive oil (intraperitoneal injection at 0.5 mg/kg body weight), group III was given with CCl4+standard drug sylimarin (100 mg/kg body weight, p. o.), group IV, V and VI were administered with CCl4+MEPO at 200, 400 and 800 mg/kg orally for a period of 21 d. The liver injury was induced by the administration of CCl4 intraperitoneally with a single dose of CCl4 (0.5 mg/kg body weight) as a 1:1 (v/v) solution in olive oil.

Results: In the Hydroxyl free radical scavenging assay, the IC50 values of the test extract was found to be 72.1±1.68 as compared with the standard drug (IC50-66.3±1.02), which was considered as significant (***p<0.001). In the reducing power assay, all the absorbance values were comparable to standard ascorbic acid and showed maximum reducing ability at the concentration of 500 µg/ml. In the in vivo anti-oxidant study, administration of MEPO to injury-induced rats at the dose of 400 and 800 mg/kg, significantly increased (**p<0.001) the levels of SOD and CAT, with a significant reduction in the MDA levels.

Conclusion: The current study explored a potential source for anti-oxidants in the methanolic extract of Pleurotus ostreatus, thus seems to be protective to liver in CCl4-induced hepatic injury.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 23268
Co-Author Bhikshapathi, Darna
773 0# - HOST ITEM ENTRY
Title International journal of pharmacy and pharmaceutical science
Place, publisher, and date of publication Bhopal Innovare Academic Sciences Pvt Ltd
International Standard Serial Number 2656-0097
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://journals.innovareacademics.in/index.php/ijpps/article/view/49478
Link text Click here
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Source of classification or shelving scheme
Koha item type Articles Abstract Database
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Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Barcode Date last seen Price effective from Koha item type
          School of Pharmacy School of Pharmacy Archieval Section 2024-04-20 2024-0460 2024-04-20 2024-04-20 Articles Abstract Database
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