Antioxidant and inhibitory effect of selected ghanaian vegetables on nitric oxide expression in lipopolysaccharide-induced macrophage cells (Record no. 20907)

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fixed length control field 240423b xxu||||| |||| 00| 0 eng d
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Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 23273
Author Attah, Ebenezer ofori
245 ## - TITLE STATEMENT
Title Antioxidant and inhibitory effect of selected ghanaian vegetables on nitric oxide expression in lipopolysaccharide-induced macrophage cells
250 ## - EDITION STATEMENT
Volume, Issue number Vol.15(12), Dec
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Bhopal
Name of publisher, distributor, etc. Innovare Academic Sciences Pvt Ltd
Year 2023
300 ## - PHYSICAL DESCRIPTION
Pagination 1-5p.
520 ## - SUMMARY, ETC.
Summary, etc. Objective: Nitric oxide (NO) is a signaling molecule that plays a key role in the pathogenesis of inflammation. Inhibitors of NO may be useful candidates for the treatment of inflammatory diseases. The study aimed to determine the antioxidant and inhibitory effect of commonly used Ghanaian vegetables, namely Corchorus olitorius (CO), Solanum melongena (SM), Solanum torvum (ST), Xanthosoma sagittifolia (XS) and Abelmoschus esculentus (AE) on NO expression in a Lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cell line.

Methods: The cytotoxic effects of the vegetables on the cell line were determined using a tetrazolium-based colorimetric assay. The inflammatory activity was determined by measuring the inhibition of NO production in LPS-induced RAW 264.7 macrophage cells. Total antioxidant activity, total phenolic, flavonoid, and reduced glutathione contents were evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, Folin-Ciocalteu, aluminium chloride, and O-Phthalaldehyde methods, respectively.

Results: Our results showed that CO and ST significantly inhibited NO production in a concentration-dependent manner with good cell viability. Solanum torvum also exhibited strong antioxidant activity (IC50= 0.466±0.23 mg/ml) with total phenolic content of 230.73±1.84 mg/g GAE, while CO showed high flavonoid content (291.45±2.14 mg/g QUE). Abelmoschus esculentus recorded the highest glutathione content (58.6 µg/g GSH. Saponins, alkaloids, tannins, terpenoids, and cardiac glycosides were present in all the samples except SM and AE, which lacked terpenoids.

Conclusion: These findings suggest that CO and ST possess anti-inflammatory and antioxidant activities that could be explored as potential therapeutic remedies for inflammatory disorders.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 23274
Co-Author Aning, Abigail
773 0# - HOST ITEM ENTRY
International Standard Serial Number 2656-0097
Place, publisher, and date of publication Bhopal Innovare Academic Sciences Pvt Ltd
Title International journal of pharmacy and pharmaceutical science
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://journals.innovareacademics.in/index.php/ijpps/article/view/47781
Link text Click here
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Koha item type Articles Abstract Database
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          School of Engineering & Technology School of Engineering & Technology Archieval Section 2024-04-23 2024-0465 2024-04-23 2024-04-23 Articles Abstract Database
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