| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20181210101521.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
181210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6923 |
| Author |
Bangale, G. S. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Development and optimization of lipsomal drug delivery system by 3/2 factorial design for cancer therapy |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol. 55 (05) May |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Drug Manufacture's Association - IDMA |
| Year |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
14-24 |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The objective of the present study was to develop nano range liposomal formulation for cancer therapy and optimize the formulation by response surface method, i.e. 32 factorial design, in order to minimize more efforts, time and material use when formulation like the liposomes are developed. Two independent variables, namely, the concentration of lipid (X1) and the concentration of cholesterol (X2), were set at three different levels. High and low levels of each variable were coded as 1 and -1, respectively, and the mean value was coded as zero. The dependent variables for factorial batches measured as vesicle size (Y1) was 61.5 to 72.3%, and % encapsulation efficiency (Y2) was found to be 127 to 240 nm. Stepwise regression analysis was used to find out the control factors that significantly affect response variables. The results were subjected to ANOVA and multiple regression analysis that led to equations describing the effect of independent variables on the selected responses. The level of significance selected was 5% (p<0.05). Contour plot and response surface plot were constructed & overlay plot was used to optimize the formulation by keeping the desired responses. The optimized formulation CL-10 has vesicle size of 132 nm & PDI value of 0.241. Zeta potential of formulation was -20.4, conforming the formulations stability. Vesicular morphology measured by SEM & TEM study indicates that the vesicle was spherical in nature. Stability study of optimized formulation was carried out for 6 months as per ICH guidelines at 40C and 370C and indicates no significant changes in parameters like % drug release, vesicle size, % EE supported by student t test (p=0.05). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 653 ## - Keywords |
|---|
| Keywords |
Liposomes |
| 653 ## - Keywords |
|---|
| Keywords |
pH gradient method |
| 653 ## - Keywords |
|---|
| Keywords |
Anova |
| 653 ## - Keywords |
|---|
| Keywords |
Student t test |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6924 |
| Co-Author |
Rajesh, K. S. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6925 |
| Co-Author |
Shinde. G. V. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
Mumbai Indian Drug Manufactures Association |
| Title |
Indian drugs |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
