| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20181210111659.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
181210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6933 |
| Author |
Samuel, P. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Bioprospecting of marine halophyte salicornia europaea L. and evaluation of its biological potential with special reference to anticancer activity |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol. 55 (05) May |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Drug Manufacture's Association - IDMA |
| Year |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
47-56 |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The study was caried out with the intention to bring out the biological prospective nature of the marine halophyte Salicornia europaea L. The bioactive phytochemicals of the halophyte were extracted. The chemicals in the crude extract were evaluated for cytotoxic activity against MCF7 cell line by MTT assay. The marine halophyte a was collected, washed and chopped into 5cm long parts and shade dried for 20 – 25 days in a dark room. The dehydrated and bleached plant material was subjected to Soxhlet extraction. Two solvents, viz methanol and ethyl acetate, were used to prepare decoction. The extracts were dried using rotary vacuum evaporator. chemical screening by GC-MS unveiled the presence of 32 compounds in ethyl acetate and 29 in methanol. The 3D structures of the phytochemicals were retrieved from Pub Chem. Cytotoxic study showed promising results. The IC50 values of the individual extracts were evaluated and ethyl acetate extract exhibit minimum IC50 value and it was estimated to be 97.9μg/mL wereas methanol extract exhibit a minimum IC50 value of 117.1μg/mL. Hence, the study concludes that S. europaea L. provides a promising source of lead compounds that could be exploited in near future to treat cancer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 653 ## - Keywords |
|---|
| Keywords |
GC-MS |
| 653 ## - Keywords |
|---|
| Keywords |
Soxhtel extraction |
| 653 ## - Keywords |
|---|
| Keywords |
MCF7 |
| 653 ## - Keywords |
|---|
| Keywords |
MTT assay |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6934 |
| Co-Author |
Vijay, Kumar |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6935 |
| Co-Author |
Selvarathinam, T. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
Mumbai Indian Drug Manufactures Association |
| Title |
Indian drugs |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
