| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20181210153521.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
181210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6944 |
| Author |
Upadhyay, P. K. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Evolving concept of caveolins and intermediary role in various mechanisms via biomolecular pathways |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol. 55 (04) April |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Drug Manufacture's Association - IDMA |
| Year |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
7-17 |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Caveolins are integral membrane proteins which consist of caveolae, present in plasma membrane. Many researchers have reported the role of caveolae in major physiological conduits of the mammalian cells, including cholesterol homeostasis, transcytosis and endocytosis. Caveolin also play a role in ischemic preconditioning of heart, postmenopausal women, brain microvessels, cancer progression and Alzheimer’s disease. Attenuation of myocardial protection in diabetic heart may be due to decrease in the ischemic preconditioning mediated release of nitric oxide, upregulation of caveolin and consequently decrease in activity of endothelial nitric oxide synthase (eNOS). Caveolin alogwith integral membrane proteins overexpress in a huge range of tumor entities, while hormonal changes cause variation in caveolin expression. Under ovariectomy conditions, eNOS inhibitory action occurs because of interaction between eNOS and caveolin. Some new concepts explain that multiple proteins, including caveolin-1 alter trans-membrane flux of fatty acid and play role in fatty acid uptake. Caveolin can be useful in the controlling of cardiovascular system (CVS) and brain disease using various predicaments. New intermediate steps have been discovered which correlate various mechanisms of ischemic preconditioning, cardiopotection and eNOS in the field of cardiovascular research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 653 ## - Keywords |
|---|
| Keywords |
Ischemic |
| 653 ## - Keywords |
|---|
| Keywords |
Preconditioning |
| 653 ## - Keywords |
|---|
| Keywords |
Nitric oxide |
| 653 ## - Keywords |
|---|
| Keywords |
Overiectomy |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
6945 |
| Co-Author |
Vishwakarma, V. K. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Indian drugs |
| Place, publisher, and date of publication |
Mumbai Indian Drug Manufactures Association |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
