| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20190314103049.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
181213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
7044 |
| Author |
Kumar, S. S. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Determination of Acetaldehyde Content in Candesartan Cilexetil by HPLC |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol. 80 (04) July-August |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Year |
2018 |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
744-748 |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
A sensitive, cost-effective, reproducible high-performance liquid chromatography method was developed and validated for quantitative determination of acetaldehyde in candesartan cilexetil using the concept of threshold of toxicological concern. Acetaldehyde is reacted with 2,4-dinitrophenylhydrazine to form a Schiff base product with an absorbing maximum at 364 nm. Effective chromatographic separation was achieved on an Inertsil ODS 3V, 250×4.6 mm, 5 µm column with a mobile phase of 40:60 v/v water and acetonitrile and at a flow rate of 1.0 ml/min. The column temperature was controlled at 25° and the injection volume was 30 µl. These conditions resolved the dinitrophenylhydrazine-acetaldehyde product with unreacted dinitrophenylhydrazine, the drug substances and related impurities, as well as diluent peak within 20 min. The retention time of dinitrophenylhydrazine-acetaldehyde product was approximately 10.6 min. The method was linear, accurate, precise, specific, rapid and found suitable for this analysis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 653 ## - Keywords |
|---|
| Keywords |
Impurity |
| 653 ## - Keywords |
|---|
| Keywords |
TTC |
| 653 ## - Keywords |
|---|
| Keywords |
DNPH |
| 653 ## - Keywords |
|---|
| Keywords |
Validation |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
7045 |
| Co-Author |
Srivastava, R. K. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Indian journal of pharmaceutical sciences |
| International Standard Serial Number |
0250-474X |
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Link text |
Click here |
| URL |
http://www.ijpsonline.com/articles/determination-of-acetaldehyde-content-in-candesartan-cilexetil-by-hplc-3523.html |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
