000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20190314110326.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
181224b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
7138 |
Author |
Baskaran, R. |
245 ## - TITLE STATEMENT |
Title |
Poly(lactic-co-glycolic acid) Microspheres Containing a Recombinant Parathyroid Hormone (1-34) for Sustained Release in a Rat Model |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol. 80(05), September-October |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Mumbai |
Year |
2018 |
Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
837-843 |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Recombinant parathyroid hormone (1-34), the drug of choice for treating severe osteoporosis, has a short half-life and requires daily subcutaneous injections. Controlled release formulation of recombinant parathyroid hormone (1-34) might prevent daily injections and improve therapeutic outcome. In this study, recombinant parathyroid hormone (1-34)-loaded poly(D,L-lactic-co-glycolic acid) microspheres using a double emulsion method were prepared. Scanning electron microscopy proved that the microspheres were spherical in shape with 2.0 to 5.0 µm diameter. A loading efficiency up to 84 % was achieved in the optimized formulation. Release study performed using microspheres of 10:1.0 polymer:drug ratio formulation revealed that the release of recombinant parathyroid hormone (1-34) was controlled over 22 days in a biphasic manner with an initial burst and a subsequent slow release. For pharmacokinetic study, recombinant parathyroid hormone (1-34)-loaded poly(D,L-lactic-co-glycolic acid) microspheres were subcutaneously injected to rats at 0.01 mg/kg dose of recombinant parathyroid hormone (1-34). Plasma drug concentration of recombinant parathyroid hormone (1-34)-loaded poly(D,L-lactic-co-glycolic acid) microspheres were maintained for a week whereas free recombinant parathyroid hormone (1-34) was quickly eliminated within a day. These results suggest that recombinant parathyroid hormone (1-34)-loaded poly(D,L-lactic-co-glycolic acid) microspheres appear to have the potential for further clinical development. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
653 ## - Keywords |
Keywords |
Osteoporosis |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
7139 |
Co-Author |
Lee, C. J. |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
7140 |
Co-Author |
Kang, S. M. |
773 0# - HOST ITEM ENTRY |
International Standard Serial Number |
0250-474X |
Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
Title |
Indian journal of pharmaceutical sciences |
856 ## - ELECTRONIC LOCATION AND ACCESS |
Link text |
Click here |
URL |
http://www.ijpsonline.com/articles/polylacticcoglycolic-acid-microspheres-containing-a-recombinant-parathyroid-hormone-134-for-sustained-release-in-a-rat-model-3537.html |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |