| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20190314114340.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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181227b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
7256 |
| Author |
Uyumlu, A. |
| 245 ## - TITLE STATEMENT |
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| Title |
Effects of Calcium Channel Blockers on Trypsinogen Activation and Severity of Cerulein-induced Acute Pancreatitis in Rats |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol. 80(03), September-October |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Mumbai |
| Year |
2018 |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
496-502 |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Acute pancreatitis is an inflammatory disease of the pancreas associated with high mortality but without a specific therapy. Intrapancreatic protease activation appears to be an early event in the development of acute pancreatitis but its association with pathogenesis has not been established. Recently it has been demonstrated that an enormous rise in the cytoplasmic Ca2+ levels of pancreatic acinar cells could be associated with the development of acute pancreatitis, thereby suggesting that Ca2+ channel could be a potential target for treatment. In this study, the protective effects of calcium channel blockers such as 2-aminoethoxydiphenyl borate, dantrolene and verapamil were investigated in cerulein-induced acute pancreatitis in vivo. Rats were divided into five groups. Group 1 (control), group 2 (cerulein, 100 µg/kg), group 3 (cerulein+ 2-aminoethoxydiphenyl borate, mg/kg), group 4 (cerulein+dantrolene, 10 mg/kg) and group 5 (cerulein+verapamil, 2.5 mg/kg). Activities of amylase, lipase, cathepsin B, pancreatic secretory trypsin inhibitor and trypsin and levels of trypsinogen activation peptide and trypsinogen were measured addition to histological examination of the sections of pancreas. The results showed that cerulein increased the amylase, lipase and trypsin activities and trypsinogen activation peptide levels significantly. Administration of calcium channel blockers significantly protected the pancreas from histological damage (p<0.05). The results of this study demonstrated that calcium channel blockers can mitigate early protease activation and pancreas injury. It was suggested regulation of calcium channels would be relevant to maintain pancreatic acinar cell homeostasis and further research is necessary to understand the protective effects of calcium channel blockers. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 653 ## - Keywords |
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| Keywords |
2-aminoethoxydiphenyl borate |
| 653 ## - Keywords |
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| Keywords |
Dantrolene |
| 653 ## - Keywords |
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| Keywords |
Verapamil |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
7257 |
| Co-Author |
Satilmis, B. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
7258 |
| Co-Author |
Batcioglu, K. |
| 773 0# - HOST ITEM ENTRY |
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| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| International Standard Serial Number |
0250-474X |
| Title |
Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Link text |
Click here |
| URL |
http://www.ijpsonline.com/articles/effects-of-calcium-channel-blockers-on-trypsinogen-activation-and-severity-of-ceruleininduced-acute-pancreatitis-in-rats-3491.html |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
