| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20190314145512.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190301b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
7792 |
| Author |
Afroze Alam |
| 245 ## - TITLE STATEMENT |
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| Title |
Anti-Leishmanial Activity of Flavanone Analogues Targeting Pteridine Reductase |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol. 52(3), July-September |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Bengaluru |
| Year |
2018 |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
480-491 |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Objectives: The aim of the study is to develop new synthetic anti-leishmanial agents as flavanone analogues, which should have low toxicity with noticeable yield. Methodology: The starting materials for the synthesis of test compounds were 2’-hydroxypropiohenones, 2’-hydroxyacetophenone and substituted benzaldehyde. Test compounds were synthesized by three steps reaction starting from condensation, cyclization and reduction to yield 3-substituted flananone analogues. The synthesized compounds were screened by in vitro anti-leishmanial assay against promastigotes of L. donovani. Result: A series of flavanone analogues have been synthesized using cobalt (II) phthalocyanine and NaBH4 in the equimolar ratio of the reactant with noticeable yield. The structures of the test compounds were elucidated and established by U.V. IR, 1H-NMR, 13C-NMR and mass spectrometry. The synthesized compounds were screened by in vitro antileishmanial assay against promastigotes of L. donovani. Conclusion: Most of the compounds exhibited moderate leishmanicidal activity, while some compounds such as 4b, 10b, 5b, and 3a have shown promising antileishmanial activity against promastigotes of L. donovani. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
7793 |
| Co-Author |
Pandit, Vinay |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
7794 |
| Co-Author |
Shailendra Kumar |
| 773 0# - HOST ITEM ENTRY |
|---|
| International Standard Serial Number |
0019-5464 |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title |
Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Link text |
Click here |
| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_3_480.pdf |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
